Results 131 to 140 of about 2,492 (169)

Simultaneous blood and biliary sampling of esculetin by microdialysis in the rat

Life Sciences, 1999
Biliary excretion and intestinal reabsorption in enterohepatic circulation play major dispositional roles for some drugs. To circumvent multiple blood sampling and interruption of enterohepatic circulation in conventional biliary cannulation, the present study utilized the minimally invasive sampling technique of microdialysis in pharmacokinetics and ...
T H, Tsai, C T, Huang, A Y, Shum, C F, Chen   +3 more
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Enzymatic transformation of esculetin as a potent class of α-glucosidase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2023
A rapid and simple enzymatic transformation of the representative coumarin esculetin (1) with polyphenol oxidase originating from Agaricus bisporus afforded five new oxidized metabolites, esculetinins A (2), B (3), C (4), D (5), and E (6), together with the known compound isoeuphorbetin (7).
Gyeong, Han Jeong, Jae-Hyeon, Cho, Kwang-Il, Park, Kyungho, Kim, Tae, Hoon Kim   +4 more
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Conversion of Caffeic Acid to Esculetin during Paper Chromatography

Nature, 1959
ESCULETIN was found in an extract of plant tissue which contained caffeic acid. The esculetin was not a natural product but was formed from caffeic acid during the paper-chromatographic purification procedures. This conversion was confirmed by two-dimensional chromatography of authentic caffeic acid.
W L, BUTLER, H W, SIEGELMAN
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Evaluation of Percutaneous Absorption of Esculetin: Effect of Chemical Enhancers

Planta Medica, 2012
Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorption of esculetin, we validated a simple, accurate, precise, and rapid HPLC-UV method ...
Sergio, del Rio Sancho, César Eulogio, Serna Jiménez, María Aracely, Calatayud Pascual, Cristina, Balaguer Fernández, Andrés, Femenía Font, Encarna, Castillo García, Virginia, Merino, Alicia, López Castellano   +7 more
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Electrochemical Behavior of Esculetin on Glassy Carbon Electrode

ECS Transactions, 2010
The electrochemical behavior of esculetin was investigated by cyclic voltammetry on glassy carbon electrode. The experimental conditions, such as supporting electrolyte and pH value, were tested for the electrochemical characterization of esculetin. It was shown that, in acetate buffer, the electrochemical behavior of esculetin had good reversibility.
Yatao Chen, Ping He, Yan Liang, Lanying Cheng, An Xia, Tinghong Zhang   +5 more
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Glucosylation of esculetin by plant cell suspension cultures

Plant Cell, Tissue and Organ Culture, 1984
Cell suspension cultures of Lithospermum erythrorhizon, Gardenia jasminoides and Nicotiana tabacum were capable of glucosylating esculetin to esculin (7-hydroxycoumarin-6-O-β-D-glucoside). Especially, a culture strain of Lithospermum erythrorhizon was superior in the esculetin glucosylating capability; 40 to 50% of esculetin administered to the culture
M. Tabata, Y. Umetani, K. Shima, S. Tanaka   +3 more
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Esculetin and idebenone ameliorate galactose‐induced cataract in a rat model

Journal of Food Biochemistry, 2020
Cataract is the principal cause of blindness. The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of
Nermin Abdel Hamid Sadik, Noha Ahmed El‐Boghdady, Nesreen Nabil Omar, Hager Abd Al‐Hamid   +3 more
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ChemInform Abstract: Improved Synthesis of Esculetin.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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EFFECTS OF ESCULETIN AS A LIPOXYGENASE INHIBITOR IN SOYBEAN EXTRACTS

Journal of Food Lipids, 1997
ABSTRACTThis study was designed to determine the ability of esculetin to inhibit lipoxygenase activity in soybean. Lipoxygenase was extracted from ground soybean using 0.1 M Tris‐HCl buffer (pH 8.6) and centrifuged at 3000 g for 15 min at 4C. The extract was mixed with different volumes of 0.05M esculetin solutions to provide 1.8 × 10−4M, 3.3 × 10−4M ...
KI‐TEAK LEE, DORRIS A. LILLARD
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HPLC Determination of Esculin and Esculetin in Rat Plasma for Pharmacokinetic Studies

Journal of Chromatographic Science, 2015
An optimized, sensitive and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method with UV detection is described for simultaneous determination of esculin and its aglycone, esculetin, in rat plasma. After addition of internal standard (chrysin), plasma samples were pretreated by solid-phase extraction and introduced into the ...
Shaheed Ur, Rehman, In Sook, Kim, Ki Sung, Kang, Hye Hyun, Yoo   +3 more
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