Results 151 to 160 of about 2,995 (191)
Anti-inflammatory and peripheral analgesic activity of esculetin in vivo
Pharmacological Research Communications, 1988 Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.
TUBARO, AURELIA +4 more
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Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis
Lipids and Lipid Metabolism, 1983Esculetin (6,7-dihydroxycoumarin) showed inhibitory effects on 5- and 12-lipoxygenases of cloned mastocytoma cells. The half-inhibition dose (ID50) for each enzyme was 4 X 10(-6) and 2.5 X 10(-6) M, respectively. No inhibition at all, but rather a stimulating effect on prostaglandin synthesis, was observed, especially at higher doses of esculetin ...
T, Neichi, Y, Koshihara, S, Murota
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Esculetin: A review of its pharmacology and pharmacokinetics
Phytotherapy Research, 2021AbstractEsculetin is a natural dihydroxy coumarin; it is mainly extracted from twig skin and the trunk bark of the Chinese herbal medicineFraxinus rhynchophyllaHance. Emerging evidence suggests that esculetin has a wide range of pharmacological activities.
Linlin Zhang, Qingxuan Xie, Xiaofang Li
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The In Vivo Effect of Esculetin Ointment and Esculetin-Mixed Zyderm for Zyderm
Plastic and Reconstructive Surgery, 2014Injectable collagen is often used for treatment of wrinkles or scars in cosmetic surgery. However, it is degraded within a short period after subcutaneous injection. The authors aimed to achieve a long-lasting effect of the filler with a new collagenase inhibitor, esculetin (6,7-dihydroxy-2H-chromen-2-one).Nude mice were divided into two study groups ...
Hisayo, Yamaoka +6 more
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Microdetermination of esculetin in Nicotiana tabacum
Analytical Biochemistry, 1973Abstract A glc method has been described for the quantitative analysis of tobacco (and other plant tissue) for esculetin (as free esculetin and the glucosides esculin or cichoriin) which used tritium-foil electron-capture detection of as little as 15 ng esculetin.
T H, Vaughn, R A, Andersen
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Journal of Biochemical and Molecular ToxicologyDoxorubicin (DOX) is an anthracycline antibiotic widely employed to treat carcinoma. Nevertheless, severe cardiotoxic side effects restrict its clinical use. Esculetin, a natural flavonoid, is found abundantly in plants.
Duygu Kizir +2 more
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Conversion of Caffeic Acid to Esculetin during Paper Chromatography
Nature, 1959ESCULETIN was found in an extract of plant tissue which contained caffeic acid. The esculetin was not a natural product but was formed from caffeic acid during the paper-chromatographic purification procedures. This conversion was confirmed by two-dimensional chromatography of authentic caffeic acid.
W L, BUTLER, H W, SIEGELMAN
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Enzymatic transformation of esculetin as a potent class of α-glucosidase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2023A rapid and simple enzymatic transformation of the representative coumarin esculetin (1) with polyphenol oxidase originating from Agaricus bisporus afforded five new oxidized metabolites, esculetinins A (2), B (3), C (4), D (5), and E (6), together with the known compound isoeuphorbetin (7).
Gyeong, Han Jeong +4 more
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Simultaneous blood and biliary sampling of esculetin by microdialysis in the rat
Life Sciences, 1999Biliary excretion and intestinal reabsorption in enterohepatic circulation play major dispositional roles for some drugs. To circumvent multiple blood sampling and interruption of enterohepatic circulation in conventional biliary cannulation, the present study utilized the minimally invasive sampling technique of microdialysis in pharmacokinetics and ...
T H, Tsai +3 more
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Esculetin and idebenone ameliorate galactose‐induced cataract in a rat model
Journal of Food Biochemistry, 2020Cataract is the principal cause of blindness. The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of
Nermin Abdel Hamid Sadik +3 more
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