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ESCULETIN PREVENTS LIVER DAMAGE INDUCED BY PARACETAMOL AND CCL4

open access: yesPharmacological Research, 1998
Esculetin, a phenolic compound found in Cichorium intybus and Bougainvllra spectabillis was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at the dose of 1 g kg-1 in mice while pre-treatment of animals with esculetin (6 mg kg-1) reduced the death rate to 40%. Oral
Anwarul Hassan Gilani   +2 more
exaly   +4 more sources
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Induction of apoptosis by esculetin in human leukemia cells

European Journal of Pharmacology, 2001
Esculetin, a coumarin compound, has been shown to exhibit antioxidant and anti-inflammatory effects. In the present study, esculetin was found to inhibit the survival of human promyelocytic leukemia HL-60 cells in a concentration-dependent and time-dependent manner.
Chia-Yih Chu   +2 more
exaly   +3 more sources

Electrochemical Behavior of Esculetin on Glassy Carbon Electrode

open access: yesECS Transactions, 2010
The electrochemical behavior of esculetin was investigated by cyclic voltammetry on glassy carbon electrode. The experimental conditions, such as supporting electrolyte and pH value, were tested for the electrochemical characterization of esculetin. It was shown that, in acetate buffer, the electrochemical behavior of esculetin had good reversibility.
Yatao Chen   +5 more
openaire   +2 more sources

Selective inhibition of platelet lipoxygenase by esculetin

Lipids and Lipid Metabolism, 1982
The effects of coumarin and its derivatives on rat platelet lipoxygenase and cyclooxygenase activities were studied. Esculetin (6,7-dihydroxycoumarin) was found to inhibit the lipoxygenase more strongly than the cyclooxygenase; its concentration for 50% inhibition (IC50) was 0.65 microM for platelet lipoxygenase and 0.45 mM for platelet cyclooxygenase.
Okuda Hiromichi
exaly   +3 more sources

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