Results 81 to 90 of about 7,313 (199)

Treating Treatment-resistant Depression with Esketamine Nasal Spray When All Therapeutic Options Have Been Exhausted: Clinical Experience from a Spanish Cohort of Expanded Use [PDF]

Depressive disorder; Esketamine; Treatment-resistantTrastorno depresivo; Esketamina; Resistente al tratamientoTrastorn depressiu; Esketamina; Resistent al tractamentObjective: Treatment Resistant Depression (TRD) is commonly defined as the lack of ...
Inzoli, Benedetta, LÓPEZ, Antonia, Ramos-Quiroga, Josep Antoni, Rodriguez-Urrutia, Amanda, Soto-Angona, Óscar, Vendrell Serres, Júlia   +5 more
core   +1 more source

The Ketamine Trial for Acute Suicidality (KETA): Study Protocol of a Double‐Blind Randomized Placebo‐Controlled Superiority Trial on Intranasal Racemic Ketamine Compared to the Active Placebo Intranasal Midazolam as Treatment for Acute Suicidality

International Journal of Methods in Psychiatric Research, Volume 34, Issue 4, December 2025.
ABSTRACT Background Suicidality is a transdiagnostic entity in patients with and without psychiatric disorders. Ketamine is a novel treatment for treatment‐resistant depression with favorable effects on related suicidality in this population. Little is known about the effects of ketamine on suicidality as a distinct phenomenon.
Jurriaan F. M. Strous, Gijs H. J. Roelandt, Jens H. van Dalfsen, Jeanine Kamphuis, Radboud M. Marijnissen, Robert A. Schoevers   +5 more
wiley   +1 more source

Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway

Kaohsiung Journal of Medical Sciences
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway ...
Hu‐Jun Xu, Xian‐Peng Li, Li‐Ye Han
doaj   +1 more source

Longitudinal trajectories of major depressive disorder provide further clinical perspectives for precision psychiatry

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Major depressive disorder (MDD) is a common and debilitating disorder. MDD was considered to be a relatively benign disorder compared to other major psychiatric disorders. However, longitudinal research revealed heterogeneous and frequently chronic course.
Murat İlhan Atagün
wiley   +1 more source

Effect of pretreatment with low-dose Esketamine on the Propofol requirements and the onset time of cisatracurium during the induction of general anesthesia: a prospective, randomized, double-blinded trial

BMC Anesthesiology
Background Esketamine has been increasingly used as an adjuvant for propofol-based induction. However, the effective esketamine dose for this indication remains unclear.
Rui An, Chunnan Lin, Zeguang Lu, Wenqian Lin, Hongying Tan, Tianhua Zhang, Huiting Li, Longhui Cao   +7 more
doaj   +1 more source

Global Trends and Hotspots in Esketamine Research: A Bibliometric Analysis of Past and Estimation of Future Trends

Drug Design, Development and Therapy, 2022
Xiang Li,1 Ping Xiang,2 Jianfen Liang,1 Yifan Deng,1 Jingyi Du1 1Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, People’s Republic of China; 2Department of Medical Quality Management, Nanfang ...
Li X, Xiang P, Liang J, Deng Y, Du J
doaj  

EFFICACY OF INTRANASAL ESKETAMINE AS A NOVEL RAPID ANTIDEPRESSANT IN ADULTS WITH TREATMENT- RESISTANT DEPRESSION [PDF]

, 2023
Major depressive disorder (MDD), the leading cause of disability worldwide is a common and disabling mental health disorder associated with high suicide-related morbidity and mortality rates.
Annalicia Setiawan, Aurielle, Arruda Supinto, Pedro, Eldy, Eldy, Sabhinaya, Sartika, Tjahyanto, Teddy   +4 more
core   +1 more source

Duration of Effects from Esketamine vs TMS Therapy in Resolving Suicidal Ideations [PDF]

, 2023
Objective: In adults with major depressive disorder (MDD), does Esketamine treatment result in longer term results of reducing suicidal ideations when compared to transcranial magnetic stimulation (TMS) therapy over the course of their lifetime? Methods:
Cameron, Samantha
core   +1 more source

Prefrontal neurophysiological changes associated with subanesthetic esketamine accelerating mice emergence from propofol anesthesia

Brain Research Bulletin
Background: Recent studies have demonstrated that subanesthetic dose of ketamine or its S-enantiomer, esketamine, can paradoxically accelerate the recovery of consciousness in rodents following general anesthesia.
Yinying Sun, Bo Li, Yiting Wang, Xuliang Jiang, Su Tang, Jiayi Zhang, Jun Zhang   +6 more
doaj   +1 more source

Case report: two cases of rhabdomyolysis following esketamine treatment

Frontiers in Psychiatry
Major depressive disorder is a mental disorder affecting millions of people worldwide. A considerable proportion of patients demonstrate a lack of response to conventional treatment.
René Zeiss, Melissa Schweizer, Bernhard Connemann, Kathrin Malejko   +3 more
doaj   +1 more source