Results 241 to 250 of about 7,916,692 (304)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis. [PDF]

Elife
Geher SWR, Falekun S, Pita-Aquino JN, Swift RP, Okada M, Jami-Alahmadi Y, Wohlschlegel JA, Prigge ST, Sigala PA.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Plant Essential Oils and Chronic Inflammatory Diseases: A Panoramic View of Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Huang J, Jiang Z, Zhou X, Zhao Z, Liu X, Zhao S, Xiong W, Qu X, Chen H, Chen H, Ding Z, Fan Y, Yang M, Xu H.   +13 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A general framework for fidelity assessment. [PDF]

Front Health Serv
Fixsen DL, Van Dyke MK, Blase KA.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A New Antibacterial Protocol Based on <i>Cymbopogon nardus</i> (L.) Rendle Essential Oil and UV-C Radiation with Potential Application for Hatching Eggs. [PDF]

Antibiotics (Basel)
Oliveira GDS, McManus C, Delgado F, Domingues J, Oliveira Filho JG, Salgado CB, Sousa HAF, Dos Santos VM.   +7 more
europepmc   +1 more source

Thermoresponsive Nanogel Incorporating <i>Duguetia stelechantha</i> Essential Oil: Biological Activity against <i>Leishmania</i> and <i>Aedes aegypti</i> Larvae. [PDF]

ACS Omega
Rocha RL, Laureano AGF, Corrêa TG, Pires Souza M, Sepulveda AF, Pelosine AM, Marques Brandão C, Braga G, Holanda CA, Lera-Nonose DSSL, de Araujo DR, Costa EV, Gonçalves RS.   +12 more
europepmc   +1 more source

Effects of selected feed additives on rumen pH dynamics, physiological responses, and rumen and cecum morphometrics in feedlot beef cattle. [PDF]

PLoS One
Niehues MB, Gomes de Gouvêa DIC, Perdigão A, Carvalho VV, Acedo TS, Tamassia LFM, Martins CL, Arrigoni MB.   +7 more
europepmc   +1 more source