Results 91 to 100 of about 8,065 (240)

Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters

Angewandte Chemie, EarlyView.
Superchaotropic boron clusters are demonstrated to deliver hydrophilic glycans directly into mammalian cells, removing the need for acetylation and cytotoxic solvents such as DMSO. Azido glycans for metabolic oligosaccharide engineering, and trehalose, were delivered and the successful azido‐labelling of glycoproteins, cell surface glycans, and ...
Qiao Tang, Alexandru Ilie, Matthew I. Gibson   +2 more
wiley   +2 more sources

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Chlorination‐Driven BODIPY Fluorescent Probes for the Selective Monitoring of Myeloperoxidase Activity in Cells and Inflamed Mouse Models

Angewandte Chemie, EarlyView.
A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho, Yongyang Luo, Jeehyeon Bae, Youngmi Kim   +3 more
wiley   +2 more sources

Evaluation of Insecticide Resistance in Aedes albopictus Population from Algiers, Algeria

Insects
Since its first detection in 2010, Aedes albopictus has spread across northern Algeria, where vector control relies on the use of chemical insecticides. This study aimed to evaluate the susceptibility of Ae.
Rym Bouledroua, Amira Nebbak, Nicolas Gomez, Zakaria Abdellahoum, Mustapha Mounir Bouhenna, Slimane Boukraa, Khaldoun Bachari, Philippe Parola, Sébastien Briolant, Lionel Almeras   +9 more
doaj   +1 more source

Effet de la pectolyase Y-23 et de la cellulase Onozuka RS sur le rendement en protoplastes viables de Prunus cerasus L. [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2001
Effect of pectolyase Y-23 and cellulase Onozuka RS on the yield of viable protoplasts of Prunus cerasus L. ""Montmorency"". To isolate leaf mesophyll, leaf and root callus protoplasts of Prunus cerasus L.
Mehri-Kamoun R.
doaj  

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

MEDICAL ASPECTS OF ESTERASES: A MINI REVIEW [PDF]

, 2016
Nowadays, esterases represent high growth potential in the World Industrial Enzymes Market. The industrial applications of esterases provide an immense contribution to the eco-friendly approaches towards nature as also in the food, textile industries as ...
Gupta, Reena, Kohli, Pooja
core   +1 more source

An overview of the main pathways of metabolic resistance in insects

Invertebrate Survival Journal, 2016
Insecticides have played and still fulfil a very important role in sustainable production of food, animal feed and also as protection against disease vectors.
M Panini, G C Manicardi, G D Moores, E Mazzoni   +3 more
doaj  

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Cloning and Characterization of GDSL Esterases from Bacillus paralicheniformis T7

Biology
Esterases catalyze the hydrolysis and transesterification of short-chain fatty acid esters, and microbial esterases are used in the production of biofuels, cosmetics, food, and pharmaceuticals.
Arman Mussakhmetov, Magzhan Astrakhanov, Dmitriy Silayev, Bekbolat Khassenov   +3 more
doaj   +1 more source