Results 71 to 80 of about 119,219 (330)

Neuropathy target esterase [PDF]

Biochemical Journal, 1999
Neuropathy target esterase (NTE) is an integral membrane protein present in all neurons and in some non-neural-cell types of vertebrates. Recent data indicate that NTE is involved in a cell-signalling pathway controlling interactions between neurons and accessory glial cells in the developing nervous system.
openaire   +2 more sources

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Functional classification of esterases from leaves of Aspidosperma polyneuron M. Arg. (Apocynaceae)

Genetics and Molecular Biology, 2003
Polyacrylamide gel electrophoresis system (PAGE) and inhibition tests for biochemical characterization of alpha- and beta-esterases were used to obtain a functional classification of esterases fromAspidosperma polyneuron.
Carvalho Vanda Marilza de, Marques Rosimar Maria, Lapenta Ana Sílvia, Machado Maria de Fátima P.S.   +3 more
doaj  

Biochemical Effects of Petroselinum crispum (Umbellifereae) Essential Oil on the Pyrethroid Resistant Strains of Aedes aegypti (Diptera: Culicidae)

Insects, 2018
In ongoing screening research for edible plants, Petroselinum crispum essential oil was considered as a potential bioinsecticide with proven antimosquito activity against both the pyrethroid susceptible and resistant strains of Aedes aegypti.
Jitrawadee Intirach, Anuluck Junkum, Nongkran Lumjuan, Udom Chaithong, Pradya Somboon, Atchariya Jitpakdi, Doungrat Riyong, Danita Champakaew, Roongtawan Muangmoon, Arpaporn Chansang, Benjawan Pitasawat   +10 more
doaj   +1 more source

Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases

Biotechnology for Biofuels, 2020
Background Esterases and lipases hydrolyze short-chain esters and long-chain triglycerides, respectively, and therefore play essential roles in the synthesis and decomposition of ester bonds in the pharmaceutical and food industries.
Zhengyang Li, Long Li, Yingyi Huo, Zijun Chen, Yu Zhao, Jing Huang, Shuling Jian, Zhen Rong, Di Wu, Jianhua Gan, Xiaojian Hu, Jixi Li, Xue-Wei Xu   +12 more
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that preces the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Ruminococcal cellulosome systems from rumen to human [PDF]

, 2015
This article is protected by copyright. All rights reserved. The authors appreciate the kind assistance of Miriam Lerner (ImmunArray Ltd. Company, Rehovot, Israel) with experiments involving the MicroGrid II arrayer.
Bayer, Edward A, Bernalier-Donadille, Annick, Borovok, Ilya, Dassa, Bareket, David, Yonit Ben, Duncan, Sylvia H, Flint, Harry J, Koropatkin, Nicole M, Lamed, Raphael, Martens, Eric C, Moraïs, Sarah, White, Bryan A   +11 more
core   +3 more sources

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source

Comparison of Enzyme Secretion and Ferulic Acid Production by Escherichia coli Expressing Different Lactobacillus Feruloyl Esterases

Frontiers in Microbiology, 2020
Construction of recombinant Escherichia coli strains carrying feruloyl esterase genes for secretory expression offers an attractive way to facilitate enzyme purification and one-step production of ferulic acid from agricultural waste.
Zhenshang Xu, Zhenshang Xu, Jian Kong, Susu Zhang, Ting Wang, Ting Wang, Xinli Liu, Xinli Liu   +7 more
doaj   +1 more source