Results 151 to 160 of about 39,453 (284)

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

Draft genome sequence of <i>Brevibacillus borstelensis</i> strain BB2 isolated from a hot spring in the Cochamó Valley, Chile. [PDF]

Microbiol Resour Announc
Gonzalez A, Calisto-Ulloa N, Valdés N, Seguel-Vinés B, Aranda C, Banerjee A, Issotta F.   +6 more
europepmc   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Rational design of a lipophilic β‐galactosidase‐responsive near‐infrared probe for in vivo imaging of cellular senescence

Smart Molecules, EarlyView.
We developed a lipophilic near‑infrared probe (DCIP‑AcGal) that is specifically activated by senescence‑associated β‑galactosidase. After intravenous injection, it lights up therapy‑induced tumor senescence in living mice. Its optimized lipophilicity also enables blood‑brain barrier crossing to detect natural brain senescence ex vivo. This probe offers
Jiani Huang, Feiyi Chu, Bin Feng, Lin Chen, Peili Cen, Jing Wang, Ying Qu, Lu Hong, Fei Wu, Huanfeng Tian, Yanpeng Fang, Yuanjie Chen, Mei Tian, Wenbin Zeng, Hong Zhang, Yan Zhong   +15 more
wiley   +1 more source

Functional characterization of macrolide esterase from cyanobacteria and their potential dissemination risk. [PDF]

NPJ Antimicrob Resist
Tao H, Zhou L, Zhou Y, Wang Y, Lv H, Wang T, Xu C, Chu Y, Wang X, Song T, Lin J.   +10 more
europepmc   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Microbial Exopolysaccharides, Redox Modulation, and Antioxidant Activity in Fermented Foods. [PDF]

Antioxidants (Basel)
Boudjouan F, Perpetuini G, Tofalo R, Waché Y, Debbache NB.   +4 more
europepmc   +1 more source

Effect of Propylparaben on In Vitro Maturation of Porcine Oocytes and Embryo Development

Environmental Toxicology, EarlyView.
ABSTRACT Parabens are synthetic chemicals that, due to their antibacterial and fungicidal effects, are widely used as preservatives in food, cosmetics, and personal care products, such as shampoos, hair conditioners, body creams, soaps, deodorants, makeup, wet wipes, lotions, female hygiene products, and vaginal lubricants. Several years ago, they were
Elivier Núñez‐Macías, Fahiel Casillas, Yenny Ramírez‐Jara, Eduardo Casas, Alma López, Adyeni Barajas‐Salinas, Jaime Barraza, Brenda Casado, Ivan Bahena‐Ocampo, Lizbeth Juárez‐Rojas, Miguel Betancourt   +10 more
wiley   +1 more source

Genome-Resolved Metagenomics Reveals Thermophilic Microbial Diversity and Putative Hydrolase-Encoding Genes in the El Tatio Geothermal Field. [PDF]

Int J Mol Sci
Valenzuela B, Navarrete-Diaz I, Cayo M, Solís-Cornejo F, Zamorano P.   +4 more
europepmc   +1 more source

Route‐Dependent Toxicity and Ecological Selectivity of Melaleuca alternifolia Essential Oil in Apis mellifera Linnaeus, 1758 (Hymenoptera: Apidae)

Environmental Toxicology, EarlyView.
ABSTRACT The intensification of agricultural practices has led to an increase in the use of insecticides, raising concerns about the exposure of non‐target organisms, particularly pollinators. In this context, plant‐derived essential oils have been proposed as environmentally friendlier alternatives due to their low persistence; however, their ...
Silvane Zancanaro de Oliveira, Elizabete Artus Berte, Juliana Marceli Hofma Lopes, Cristiane Lurdes Paloschi, Edgar de Souza Vismara, Vitória Alves Pereira, Fernanda Raulino Domanski, Natália Ramos Mertz, Fabiana Martins Costa, Everton Ricardi da Silva Lozano, Jhenneffer Tainara Zancanaro Ghizzi, Michele Potrich   +11 more
wiley   +1 more source