Results 81 to 90 of about 6,088,284 (323)

Computer vision uncovers three fundamental dimensions of levodopa-responsive motor improvement in Parkinson’s disease

npj Parkinson's Disease
We developed VisionMD, an AI computer vision platform, analyzing over 1200 clinical videos of Parkinson’s patients’ hand movements across 13 years. This large-scale, markerless analysis identified three kinematic domains (speed, consistency, timing/scale)
Florian Lange, Diego L. Guarin, Esther Ademola, Dalia Mahdy, Gabriela Acevedo, Thorsten Odorfer, Joshua K. Wong, Jens Volkmann, Robert Peach, Martin Reich   +9 more
doaj   +1 more source

On Bayes estimates

Journal of Multivariate Analysis, 1973
AbstractIn this paper the author tries to give general conditions for the existence of Bayes estimates and for the consistency of sequences of Bayes estimates.In Section 3 we prove existence theorems for Bayes estimates, which contain those of DeGroot and Rao [3], as a special case.
openaire   +3 more sources

Aggregated estimating equation estimation [PDF]

Statistics and Its Interface, 2011
Motivated by the recent active research on online analytical processing (OLAP), we develop a computation and storage efficient algorithm for estimating equation (EE) estimation in massive data sets using a “divide-and-conquer” strategy. In each partition of the data set, we compress the raw data into some low dimensional statistics and then discard the
Ruibin Xi, Nan Lin
openaire   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Pengaruh Komitmen Organisasi Dan Keinginan Sosial Terhadap Partisipasi Anggaran [PDF]

, 2012
Higher/ estimation convidential of clerk less detect potential and obstacle that has by subordinate/ estimation executor so that give target very demand compared ably subordinate/ estimation executor.
Mayuni, Fifi
core  

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source