Results 91 to 100 of about 2,725 (200)

Green solvents for the hydroaminomethylation of estragole  [PDF]

, 2019
Hydroaminomethylation (HAM) is a simple route to synthesize amines through a highly atom-economic reaction of alkene with syngas (carbon monoxide/hydrogen mixture) and a primary or secondary amine.
Maria Gabriela Paredes Gutierrez
core  

Mechanism of action of relaxant effect of Agastache mexicana ssp.mexicana essential oil in guinea-pig trachea smooth muscle

Pharmaceutical Biology, 2017
Context: Agastache mexicana ssp. mexicana (Kunth) Lint & Epling (Lamiaceae), popularly known as ‘toronjil morado’, is used in Mexican traditional medicine for the treatment of several diseases such as hypertension, anxiety and respiratory disorders ...
Andrés Navarrete, Natalia Ávila-Rosas, Mateo Majín-León, José Luis Balderas-López, Alejandro Alfaro-Romero, José Carlos Tavares-Carvalho   +5 more
doaj   +1 more source

AROMATIC PLANTS FROM VIETNAM, SOURCES OF PHENYLPROPANOID PRODUCTS FOR INDUSTRY

ASEAN Journal on Science and Technology for Development, 2017
Aromatic plants produce by vapour distillation or other processes essential oils which are products with high commercial value used in the natural product industries such flavour and fragrance, perfumes and cosmetics industries as well as pharmaceutical ...
Tran Minh Hoi
doaj   +1 more source

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling

, 2012
Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure to estragole via the regular diet.
Paini, A., Gremaud, E., Schilter, B., van Bladeren, P.J., Alink, G.M., Spenkelink, A., Scholz, G., Punt, A., Bladeren, P.J., van, Rietjens, I.   +9 more
core   +1 more source

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect

, 2010
Estragole is a natural constituent of several herbs and spices including sweet basil. In rodent bioassays, estragole induces hepatomas, an effect ascribed to estragole bioactivation to 1'-sulfooxyestragole resulting in DNA adduct formation.
Paini, A., Adams, T.B., Al-Husainy, W.A.A.M., Louisse, J., Scholz, G., Delatour, T., Punt, A., Schilter, B., van Bladeren, P.J., Spenkelink, B., Vervoort, J.J.M., Bladeren, P.J., van, Rietjens, I.   +12 more
core   +1 more source

Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling

, 2016
Estragole is a known hepatocarcinogen in rodents at high doses following metabolic conversion to the DNA-reactive metabolite 1′-sulfooxyestragole. The aim of the present study was to model possible levels of DNA adduct formation in (individual) humans ...
Benoit Schilter (2412691), Alicia Paini (2570128), Ivonne M. C. M. Rietjens (286768), Peter J. van Bladeren (2570137), Albertus Spenkelink (2570134), Gabriele Scholz (2570131), Ans Punt (2012542)   +6 more
core   +2 more sources

Matrix-derived combination effect and risk assessment for estragole from basil-containing plant food supplements (PFS)

, 2013
Basil-containing plant food supplements (PFS) can contain estragole which can be metabolised into a genotoxic and carcinogenic 1'-sulfoxymetabolite. This study describes the inhibition of sulfotransferase (SULT)-mediated bioactivation of estragole by ...
van den Berg, S.J.P.L., Rietjens, Ivonne M.C.M., van den Berg, Suzanne J.P.L., Alhusainy, W., Klaus, Verena, Berg, S.J.P.L., van den, Klaus, V., Alhusainy, Wasma, Rietjens, I.   +8 more
core   +1 more source

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

, 2017
The extent of bioactivation of the herbal constituent estragole to its ultimate carcinogenic metabolite 1′-sulfooxyestragole depends on the relative levels of bioactivation and detoxification pathways.
Punt, Ans, Freidig, Andreas P., Rietjens, Ivonne M. C. M., Schilter, Benoît, Scholz, Gabriele, Bladeren, Peter J. van, Paini, Alicia, Boersma, Marelle G., Delatour, Thierry   +8 more
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In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells

, 2018
Estragole, a common component of herbs and spices, is a wellknown genotoxic hepatocarcinogen in rodents, whereas its potential toxic effect in humans is still debated.
Fatigoni, Cristina, Luca Dominici, Dominici, Luca, Claudia Zadra, Zadra, Claudia, Pagiotti, Rita, LEVORATO, SARA, Villarini, Milena, Milena Villarini, Cristina Fatigoni, Rita Pagiotti, Massimo Moretti, Sara Levorato, Moretti, Massimo   +13 more
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Matrix Modulation of the Bioactivation of Estragole by Constituents of Different Alkenylbenzene-containing Herbs and Spices and Physiologically Based Biokinetic Modeling of Possible In Vivo Effects

, 2012
The alkenylbenzene estragole is a constituent of several herbs and spices. It induces hepatomas in rodents at high doses following bioactivation by cytochrome P450s and sulfotransferases (SULTs) giving rise to the ultimate carcinogenic metabolite 1 ...
Paini, A., Schilter, B., Asselman, M., Adams, T.B., Campana, A., Spenkelink, A., Al-Husainy, W.A.A.M., Scholz, G., Berg, S.J.P.L., van den, Punt, A., Bladeren, P.J., van, Rietjens, I.   +11 more
core   +1 more source