Results 151 to 160 of about 759,583 (365)

Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease

Frontiers in Genetics
IntroductionThe deficiency of estrogen correlates with a range of diseases, notably Postmenopausal osteoporosis (PMO) and Parkinson’s disease (PD). There is a possibility that PMO and PD may share underlying molecular mechanisms that are pivotal in their
Dongdong Yu, Dongdong Yu, Jian Kang, Chengguo Ju, Qingyan Wang, Ye Qiao, Ye Qiao, Long Qiao, Long Qiao, Dongxiang Yang   +9 more
doaj   +1 more source

Estrogen receptor regulates hormone-induced growth arrest in a luminal A like breast cancer model [PDF]

, 2018
Lacey Haddon, S.C. Hu, Hosna Jabbari, Brittney Loney, Zelda-Saidman Lichtensztejn, Richard P. Fahlman, Mary Hitt, Kirk J. McManus, Kelly Dabbs, John R. Mackey, Judith Hugh   +10 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Role of Calcium in an Experimental Breast Cancer Model Induced by Radiation and Estrogen

Biomedicines
Background: Breast cancer, a global health challenge, significantly impacts women worldwide, causing morbidity, disability, and mortality. Objectives: To analyze the role of genes encoding S100 calcium-binding proteins and their relationship with ...
Gloria M. Calaf, Luis N. Ardiles, Leodan A. Crispin   +2 more
doaj   +1 more source

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source

Comparison of two ovulation tests to predict timing of the late follicular phase for menstrual cycle research in premenopausal females

Physiological Reports
Menstrual cycle peak estradiol occurs in the late follicular (LF) phase just prior to the luteinizing hormone (LH) surge and ovulation. Therefore, to examine the impact of menstrual cycle estradiol fluctuations, it is desirable to perform assessments ...
Lindsay A. Lew, Kyra E. Pyke
doaj   +1 more source

A new and alternative pharmacological protocol for endometrial preparation in oocyte donation cycles: Human menopausal gonadotrophins followed by estrogens [PDF]

, 2019
Rindra Rakotobe Andriamaro, Ramarolahy Rija, Graziella Badulli, Andriantsirombaka Rakotobe Andriamaro, L. Formigli   +4 more
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

A Population‐Based Correlation Analysis Between Hemoglobin A1c and Hemoglobin Levels

Journal of Diabetes
Background Glycated hemoglobin (HbA1c) is widely used to assess long‐term glycemic control in individuals with diabetes. However, various conditions that affect hemoglobin levels or the lifespan of red blood cells can compromise the accuracy of HbA1c ...
Tingyu Zhang, Tianyi Shi, Min Cao, Yunxi Ji, Yanbin Xue, Huayan Yao, Qiaomei Yin, Bin Cui, Zhen Xie, Ping He   +9 more
doaj   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source