Results 11 to 20 of about 16,304 (50)

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status

Endocrine Connections, 2019
The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC).
Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun, Tinghuai Wang   +5 more
doaj   +1 more source

Tributyltin Exposure Is Associated With Recognition Memory Impairments, Alterations in Estrogen Receptor α Protein Levels, and Oxidative Stress in the Brain of Female Mice

Frontiers in Toxicology, 2021
Tributyltin (TBT) is a persistent organometallic pollutant widely used in several agricultural and industrial processes. TBT exposure is associated with various metabolic, reproductive, immune, and cardiovascular abnormalities.
Igor Ferraz da Silva, Eduardo Merlo, Charles S. Costa, Jones B. Graceli, Lívia C. M. Rodrigues   +4 more
doaj   +1 more source

Human Umbilical Cord Blood Cells or Estrogen may be Beneficial in Treating Heatstroke

Taiwanese Journal of Obstetrics & Gynecology, 2007
This current review summarized animal models of heatstroke experimentation that promote our current knowledge of therapeutic effects on cerebrovascular dysfunction, coagulopathy, and/or systemic inflammation with human umbilical cord blood cells (HUCBCs)
Sheng-Hsien Chen, Kuo-Feng Huang, Mao-Tsun Lin, Fong-Ming Chang   +3 more
doaj   +1 more source

Evolutionary insights into the steroid sensitive kiss1 and kiss2 neurons in the vertebrate brain

Frontiers in Endocrinology, 2012
Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji eKanda, Yoshitaka eOka
doaj   +1 more source

Biochanin A Attenuates Ovariectomy-Induced Cognition Deficit via Antioxidant Effects in Female Rats

Frontiers in Pharmacology, 2021
Background: Impairment of memory and cognition is one of the major symptoms in women with postmenopausal disorders due to estrogen deficiency, which accounts for the much higher prevalence of Alzheimer’s disease in females.
Yanmeng Zhou, Bingbing Xu, Haiyang Yu, Wei Zhao, Xinxin Song, Yan Liu, Kainan Wang, Nikoli Peacher, Xiaomin Zhao, Han-Ting Zhang   +9 more
doaj   +1 more source

Estrogen deficiency accompanied by oxidative stress sustains heme oxygenase 1 expression in cardiomyocytes of ovariectomized rats

Journal of Medical Sciences, 2021
Background: Estrogen deficiency is one of the main causes of cardiovascular diseases (CVDs) after menopause, accompanied with the upregulation of oxidative stress.
Zheng-Zong Lai, Hsiang-Yu Yang, Ping-Nan Chen, Wei-Jou Shih, Hsin-Hsueh Shen, Yen-Mei Lee   +5 more
doaj   +1 more source

Importance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast

Indian Journal of Pathology and Microbiology, 2013
Background: Conventionally growth pattern, stromal overgrowth, stromal cellularity and stromal mitotic activity are the main parameters in the grading of phyllodes tumors (PTs).
Ulku Kucuk, Umit Bayol, Emel Ebru Pala, Suheyla Cumurcu   +3 more
doaj   +1 more source

Epigenetic factors in breast cancer therapy

Frontiers in Genetics, 2022
Epigenetic modifications are inherited differences in cellular phenotypes, such as cell gene expression alterations, that occur during somatic cell divisions (also, in rare circumstances, in germ line transmission), but no alterations to the DNA sequence
Runjhun Mathur, Runjhun Mathur, Niraj Kumar Jha, Niraj Kumar Jha, Niraj Kumar Jha, Gaurav Saini, Saurabh Kumar Jha, Saurabh Kumar Jha, Sheo Prasad Shukla, Zita Filipejová, Kavindra Kumar Kesari, Danish Iqbal, Danish Iqbal, Parma Nand, Vijay Jagdish Upadhye, Abhimanyu Kumar Jha, Shubhadeep Roychoudhury, Petr Slama   +17 more
doaj   +1 more source

Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens

Frontiers in Behavioral Neuroscience, 2022
Memory disruption commonly follows chronic stress, whereas acute stressors are generally benign. However, acute traumas such as mass shootings or natural disasters—lasting minutes to hours and consisting of simultaneous physical, social, and emotional ...
Rachael E. Hokenson, Yasmine H. Alam, Annabel K. Short, Annabel K. Short, Sunhee Jung, Cholsoon Jang, Tallie Z. Baram, Tallie Z. Baram, Tallie Z. Baram   +8 more
doaj   +1 more source

Sex difference in circulating PCSK9 and its clinical implications

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a proprotein convertase that increases plasma low-density lipoprotein cholesterol (LDL-C) levels by triggering the degradation of LDL receptors (LDLRs).
Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li   +4 more
doaj   +1 more source