Results 11 to 20 of about 924,304 (411)
Molecular mechanism of estrogen–estrogen receptor signaling [PDF]
Reproductive Medicine and Biology, 2016 Abstract17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes.
Yasar, Pelin +4 more
openaire +5 more sources
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago.
Baker, Michael E.
core +1 more source
A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer
International Journal of Molecular Sciences, 2023 Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone
Léa Clusan +3 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2022 Osteoporosis is a serious health issue among aging postmenopausal women. The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance
Chui H Cheng, Li-Ru Chen, Kuo-Hu Chen
semanticscholar +1 more source
The impact of the gut microbiota on the reproductive and metabolic endocrine system
Gut Microbes, 2021 As the gut microbiota exerts various effects on the intestinal milieu which influences distant organs and pathways, it is considered to be a full-fledged endocrine organ. The microbiota plays a major role in the reproductive endocrine system throughout a
Xinyu Qi +3 more
doaj +1 more source
Estrogen Biosynthesis and Signal Transduction in Ovarian Disease
Frontiers in Endocrinology, 2022 Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled estrogen receptor (GPER) mRNA could be detected in ovary, suggesting that they play an ...
Xue-Ling Xu +5 more
doaj +1 more source
Frontiers in Oncology, 2020 We previously showed that UBE2C mRNA expression is significantly associated with poor prognosis only in patients with hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2)– breast cancer.
Yu-Jin Kim +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Fibroblasts have been shown to be one of the essential players for mammary gland organization. Here, we identify two major types of mouse mammary gland fibroblasts through single-cell RNA sequencing analysis: Dpp4+ fibroblasts and Dpp4- fibroblasts. Each
Ryohei Yoshitake +7 more
doaj +1 more source
Journal of Circadian Rhythms, 2020 Objective: Review relationships among circadian clocks, core body temperature (CBT), and fertility in women. Methods: Scoping literature review. Results: Circadian clocks are a ubiquitous adaptation to the most predictable environmental events – the ...
Wade W. Webster, Benjamin Smarr
doaj +1 more source
Journal of the American Medical Association (JAMA), 2002 CONTEXT Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain.
J. Rossouw +11 more
semanticscholar +1 more source