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Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease
mBio, 2018 The concept of repurposing previously approved medications to the treatment of new indications by taking advantage of off-target effects has gained traction in recent years, particularly in areas of medicine that do not offer large profits to ...
Marhiah C. Montoya, Damian J. Krysan
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Mechanisms for estrogen receptor expression in human cancer
Experimental Hematology & Oncology, 2018 Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
Hui Hua +3 more
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Antagonists Selective for Estrogen Receptor α [PDF]
Endocrinology, 2002 To develop compounds that are antagonists on ER(alpha), but not ER(beta), we have added basic side-chains typically found in nonsteroidal antiestrogens to pyrazole compounds that bind with much higher affinity to ER(alpha) than to ER(beta). In this way we have developed basic side-chain pyrazoles (BSC-pyrazoles) that are high affinity, potent ...
Jun, Sun +5 more
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Estrogen alpha receptor antagonists for the treatment of breast cancer: a review
Chemistry Central Journal, 2018 Background Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030.
Deepika Sharma +2 more
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Caution over haste: why novel endocrine therapy in early lines should wait in Estrogen receptor positive human epidermal growth factor receptor 2 negative breast cancer [PDF]
Breast Cancer ResearchThe rapid development of novel endocrine therapies (ETs), such as selective estrogen receptor degraders (SERDs), proteolysis targeting chimeras (PROTACs), selective estrogen receptor covalent antagonists (SERCAs), and complete estrogen receptor ...
Lan Lei +3 more
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Impact of hormones on lipedema development: a systematic literature review [PDF]
Archives of Gynecology and ObstetricsPurpose Lipedema is a chronic disorder that affects the subcutaneous adipose tissue of the lower and upper limbs and results in painful fat accumulations.
Julia Elisabeth Lüchinger +3 more
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Estrogens, progestins, and their antagonists
Biomedicine & Pharmacotherapy, 1997 I: New Applications and Concepts Involving Estrogens and Progestins.- 1. Benefits and Risks of Hormone Replacement Therapy.- 2. Phytoestrogen Effects in Humans Relative to Risk for Cardiovascular Disease, Breast Cancer, Osteoporosis, and Menopausal Symptoms.- 3.
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An emerging generation of endocrine therapies in breast cancer: a clinical perspective
npj Breast Cancer, 2023 Anti-estrogen therapy is a key component of the treatment of both early and advanced-stage hormone receptor (HR)-positive breast cancer. This review discusses the recent emergence of several anti-estrogen therapies, some of which were designed to ...
Rima Patel +3 more
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Ecotoxicology and Environmental Safety, 2021 Protective effects of estrogen (E2) on traumatic brain injury (TBI) have been determined. In this study, the hepatoprotective effects of E2 after TBI through its receptors and oxidative stress regulation have been evaluated.
Sedigheh Amiresmaili +7 more
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Estrogen Receptor Signaling in Breast Cancer [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2023 Breast cancer is the primary cause of cancer deaths globally and the second most common cancer in women after skin cancer. There are a number of core strategies for treating cancer including surgery, radiation therapy, immunologic therapy, and chemical ...
Aya Eid
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