Results 41 to 50 of about 919,146 (322)

Characterization of estrogen and androgen activity of food contact materials by different in vitro bioassays (YES, YAS, ERα and AR CALUX) and chromatographic analysis (GC-MS, HPLC-MS). [PDF]

PLoS ONE, 2014
Endocrine active substances (EAS) show structural similarities to natural hormones and are suspected to affect the human endocrine system by inducing hormone dependent effects.
Johannes Mertl, Christian Kirchnawy, Veronica Osorio, Angelika Grininger, Alexander Richter, Johannes Bergmair, Michael Pyerin, Michael Washüttl, Manfred Tacker   +8 more
doaj   +1 more source

Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease

Neurobiology of Disease, 2013
The mechanism by which estrogen protects dopaminergic neurons has not yet been clarified. It is not known if changes in RhoA/Rho kinase activity are involved in the enhanced vulnerability of dopaminergic neurons observed after estrogen depletion.
Ana I. Rodriguez-Perez, Antonio Dominguez-Meijide, Jose L. Lanciego, Maria J. Guerra, Jose L. Labandeira-Garcia   +4 more
doaj   +1 more source

Cyclin D1b Is Aberrantly Regulated in Response to Therapeutic Challenge and Promotes Resistance to Estrogen Antagonists

Cancer Research, 2008
Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers. A number of studies have indicated that a polymorphism in a splice donor site in the cyclin D1 gene is associated with ...
Ying Wang, Jeffry Dean, E. Millar, T. Tran, C. McNeil, C. Burd, S. Henshall, F. E. Utama, A. Witkiewicz, H. Rui, R. Sutherland, K. Knudsen, E. Knudsen   +12 more
semanticscholar   +1 more source

Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells

, 1994
A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang, Angerer, S. von, Angerer, E. von, Seidl, E., Mannschreck, A.   +4 more
core   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

AMEERA-1 phase 1/2 study of amcenestrant, SAR439859, in postmenopausal women with ER-positive/HER2-negative advanced breast cancer

Nature Communications, 2022
There is a need for potent and non-toxic estrogen receptor (ER) antagonists to overcome the limitations of existing endocrine therapies. Here the authors report the results from Arm 1 of the Phase 1/2 study (AMEERA-1) among postmenopausal women with ER ...
Aditya Bardia, Sarat Chandarlapaty, Hannah M. Linden, Gary A. Ulaner, Alice Gosselin, Sylvaine Cartot-Cotton, Patrick Cohen, Séverine Doroumian, Gautier Paux, Marina Celanovic, Vasiliki Pelekanou, Jeffrey E. Ming, Nils Ternès, Monsif Bouaboula, Joon Sang Lee, Anne-Laure Bauchet, Mario Campone   +16 more
doaj   +1 more source

Epithioandrostanol (10275-S), an Estrogen Antagonist

Endocrinologia Japonica, 1973
2α, 3α-Epithio-5α-androstan-17β-ol (10275-S) has been known to possess a potent and long-acting anti-estrogenic activity in rodents. In this experiment, 1.25mg 10275-S injected once subcutaneously into the ovariectomized and estradiol-treated mice caused a complete block of vaginal cornification for 24.3 days in spite of the successive treatment with ...
MIYAKE, TAMOTSU, HORI, TAKASHI, SUZUKI, TETSURO   +2 more
openaire   +3 more sources

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific Reports, 2014
The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist and antagonist activity using two types of ER reporter gene cell lines, one ...
Ruili Huang, S. Sakamuru, Matt T. Martin, David M. Reif, R. Judson, K. Houck, W. Casey, J. Hsieh, K. Shockley, P. Ceger, J. Fostel, K. Witt, W. Tong, Daniel M. Rotroff, Tongan Zhao, P. Shinn, A. Simeonov, D. Dix, C. Austin, R. Kavlock, R. Tice, M. Xia   +21 more
semanticscholar   +1 more source

Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Clinics
Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Danylo Rafhael Costa-Silva, Carla Solange Escórcio-Dourado, Umbelina Soares Borges, Airton Mendes Conde-Junior, Maria da Conceição Barros-Oliveira, Emerson Brandão Sousa, Lorena da Rocha Barros, Luana Mota Martins, Gil Facina, Benedito Borges da-Silva   +11 more
doaj   +1 more source

Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18).

PLoS ONE, 2016
Estrogen can modulate neuronal development and signalling by both genomic and non-genomic pathways. Many of its rapid, non-genomic effects on nervous tissue have been suggested to be mediated via the activation of the estrogen sensitive G-protein coupled
Nicholas J Evans, Asha L Bayliss, Vincenzina Reale, Peter D Evans   +3 more
doaj   +1 more source