Results 31 to 40 of about 919,146 (322)
Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling
OncoTarget, 2017 Major roadblocks to developing effective progesterone receptor (PR)-targeted therapies in breast cancer include the lack of highly-specific PR modulators, a poor understanding of the pro- or anti-tumorigenic networks for PR isoforms and ligands, and an ...
H. Singhal +17 more
semanticscholar +1 more source
INDUCTION OF ENDOMETRIAL PEROXIDASE SYNTHESIS AND SECRETION BY ESTROGEN AND ESTROGEN ANTAGONIST [PDF]
The Journal of Cell Biology, 1974 Synthesis of peroxidase was induced in the uterine epithelium of immature rats by multiple doses over a 24–96-h period of either 17 ß-estradiol, the estrogen-antagonist Parke-Davis CI-628, or a combination of estradiol plus antagonist. Endogenous peroxidase activity first appeared in the cisternae of the rough endoplasmic reticulum of surface ...
A, Churg, W A, Anderson
openaire +2 more sources
ERpred: a web server for the prediction of subtype-specific estrogen receptor antagonists [PDF]
PeerJ, 2021 Estrogen receptors alpha and beta (ERα and ERβ) are responsible for breast cancer metastasis through their involvement of clinical outcomes. Estradiol and hormone replacement therapy targets both ERs, but this often leads to an increased risk of breast ...
Nalini Schaduangrat +2 more
doaj +2 more sources
Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells. [PDF]
PLoS ONE, 2014 Estrogen is implicated as an important factor in stimulating breast cancer cell proliferation, and presence of estrogen receptor (ER) is an indication of a good prognosis in breast cancer patients.
Jennifer L Schacter +2 more
doaj +1 more source
Physiological Reports, 2023 After injury, skeletal muscle regenerates thanks to the key role of satellite cells (SC). The regeneration process is supported and coordinated by other cell types among which immune cells. Among the mechanisms involved in skeletal muscle regeneration, a
Charline Jomard, Julien Gondin
doaj +1 more source
Frontiers in Cellular Neuroscience, 2019 Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi +9 more
doaj +1 more source
npj Breast Cancer, 2022 Estrogen receptor alpha (ERα) is a ligand-dependent master transcriptional regulator and key driver of breast cancer pathology. Small molecule hormones and competitive antagonists favor unique ERα conformational ensembles that elicit ligand-specific ...
G. R. Hancock +8 more
doaj +1 more source
Animals, 2021 Porcine tissue gene expression is highly similar to the expression of homologous genes in humans. Based on this fact, the studies on porcine tissues can be employed to understand human physiology and to predict or treat diseases.
Michal Duliban +6 more
doaj +1 more source
Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]
, 2005 Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core +1 more source
PLoS ONE, 2015 Progesterone receptor and estrogen receptor participate in growth and differentiation of the different rat decidual regions. Steroid hormone receptor antagonists were used to study steroid regulation of decidualization.
Ana C Mestre-Citrinovitz +4 more
doaj +1 more source