Results 21 to 30 of about 919,146 (322)

Estrogen Agonist and Antagonist Action on the Human Estrogen Receptor in Drosophila [PDF]

Endocrinology, 2000
The estrogen receptor (ER) regulates the expression of genes involved in the growth, proliferation and differentiation of skeletal, cardiovascular, neural and reproductive tissues. A basic scheme for the mechanism for ER action has been developed, but precise details on the interactions between ER and the cellular signaling and transcription machinery ...
V G, Thackray, R H, Young, J E, Hooper, S K, Nordeen   +3 more
openaire   +3 more sources

Molecular mechanisms of sex bias differences in COVID-19 mortality

Critical Care, 2020
More men than women have died from COVID-19. Genes encoded on X chromosomes, and sex hormones may explain the decreased fatality of COVID-19 in women. The angiotensin-converting enzyme 2 gene is located on X chromosomes.
Yuchong Li, Mirjana Jerkic, Arthur S. Slutsky, Haibo Zhang   +3 more
doaj   +1 more source

Estrogen Antagonist and Development of Macular Hole [PDF]

Korean Journal of Ophthalmology, 2010
To describe the clinical and optical coherence tomography (OCT) features of a macular hole (MH) or its precursor lesion in patients treated with systemic antiestrogen agents. We reviewed the medical history of the patient, ophthalmic examination, and both fundus and OCT findings. Three female patients receiving antiestrogen therapy sought treatment for
Chung, Song Ee, Kim, Seong Wook, Chung, Hye Won, Kang, Se Woong   +3 more
openaire   +2 more sources

The binding of estrogen and estrogen antagonists to the estrogen receptor

Archives of Biochemistry and Biophysics, 1992
The model of the estrogen receptor as a dimer of identical, interacting subunits and data obtained by Sasson and Notides (1988, Mol. Endocrinol. 2, 307-312) were used to find the standard free energy changes that describe the binding of estradiol and 4-hydroxytamoxifen to the estrogen receptor.
J P, Bond, S, Sasson, A C, Notides
openaire   +2 more sources

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches

Oxidative Medicine and Cellular Longevity, 2018
Estrogen receptor α (ERα) is a successful target for ER-positive breast cancer and also reported to be relevant in many other diseases. Selective estrogen receptor modulators (SERMs) make a good therapeutic effect in clinic.
Xiaocong Pang, W. Fu, Jinhua Wang, De Kang, Lv-jie Xu, Ying Zhao, Ai-lin Liu, G. Du   +7 more
semanticscholar   +1 more source

The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology

Biomolecules, 2023
Objective: Estrogen is indispensable in health and disease and mainly functions through its receptors. The protection of the cardiovascular system by estrogen and its receptors has been recognized for decades.
Fujie Xu, Jipeng Ma, Xiaowu Wang, Xiaoya Wang, Weiyi Fang, Jingwei Sun, Zilin Li, Jincheng Liu   +7 more
doaj   +1 more source

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen [PDF]

, 2012
SynthSys is a Centre for Integrative Systems Biology (CISB) funded by BBSRC and EPSRC, reference BB/D019621/1.Background: Estrogen receptors alpha (ER) are implicated in many types of female cancers, and are the common target for anti-cancer therapy ...
Harrison, David J, Kenneth Macleod, Yamaguchi, Azusa, Macleod, Kenneth, Galina Lebedeva, David J Harrison, Lebedeva, Galina, Langdon, Simon P., Langdon, Simon P, Azusa Yamaguchi, Harrison, David J., Simon P Langdon   +11 more
core   +1 more source

Development of Peptide Antagonists That Target Estrogen Receptor β-Coactivator Interactions

Molecular Endocrinology, 2000
Julie M Hall, Ching-Yi Chang, Donald P Mcdonnell   +2 more
exaly   +2 more sources

Urinary estrogen metabolites and prostate cancer : a case-control study and meta-analysis [PDF]

, 2009
Objective: To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.
Blandino Giovanni, Barba, Maddalena, Gallucci, M. (Michele), Stranges S., Grioni Sara, Michele Gallucci, Barba M., Maddalena Barba, Yang L., Holger J Schünemann, Gallucci Michele, Malorni Luca, Muti Paola, Luca Malorni, Blandino G., Schünemann, Holger J., Muti, Paola, Paola Muti, Gallucci M., Muti P., Lauria, Rossella, Francesca Sperati, Stranges, Saverio, Westerlind Kim C, Kim C Westerlind, Yang, Li, Ph.D., Malorni, Luca, Lauria Rossella, Giovanni Blandino, Westerlind, Kim C., Stranges Saverio, Sara Grioni, Barba Maddalena, Sperati, Francesca, Sperati F., Lauria R., Grioni, Sara, Sperati Francesca, Saverio Stranges, Yang Li, Malorni L., Blandino, Giovanni, Li Yang, Westerlind K. C., Schünemann Holger J, Grioni S., Rossella Lauria, Schunemann H. J.   +47 more
core   +1 more source

Single-cell states in the estrogen response of breast cancer cell lines [PDF]

, 2014
Estrogen responsive breast cancer cell lines have been extensively studied to characterize transcriptional patterns in hormone-responsive tumors. Nevertheless, due to current technological limitations, genome-wide studies have typically been limited to ...
Andrea Gamba, Nassa, Giovanni, Roberto Amendola, Mario Nicodemi (81682), Sach Mukherjee (19432), Chris J Oates, Francesco Paolo Casale (526999), Nicodemi, M, Weisz, Alessandro, Gamba, A, Jonathan, W., Alessandro Weisz (90872), Alessandro Weisz, Giorgio Giurato (527000), Giorgio Giurato, Gamba, Andrea, Cora', Davide, Chris J. Oates, Gamba, Andrea Antonio, Armond, Jonathan W., Weisz, A, Amendola, Roberto, Mukherjee, Sach, Casale, Francesco Paolo, Oates, Chris J., Jonathan W. Armond, Mario Nicodemi, Oates, CJ, Giovanni Nassa, Davide Corá, Nassa, G, Corá, Davide, Ro Weisz, Mukherjee, S, Giovanni Nassa (527001), Chris J. Oates (527003), Francesco Paolo Casale, Giurato, Giorgio, Andrea Gamba (181217), Nicodemi, Mario, Sach Mukherjee, Davide Cor?, Giurato, G, Corá, D, Chris, J., Jonathan W Armond, Davide Corá (5649682), Armond, JW, Jonathan W. Armond (527002), Casale, FP   +49 more
core   +1 more source