Results 11 to 20 of about 2,368,340 (74)
Different approaches to unveil biomolecule configurations and their mutual interactions [PDF]
Analytical Letters 54, no.1-2, 40-56 (2020), 2020 A novel technique was demonstrated that overcome important drawbacks to crosslink cells by irradiation with ultrashort UV laser pulses (L-crosslinking). To use this technique coupled to Chromatin ImmunoPrecipitation (ChIP) in a high throughput context, a pre-screening fast method needs to be implemented to set up suitable irradiation conditions of the ...
arxiv +1 more source
FMO Study of the Interaction Energy between Human Estrogen Receptor $α$ and Selected Ligands [PDF]
arXiv, 2022 Fragment molecular orbital (FMO) calculations were performed in aqueous media which allowed us to obtain the interaction energy between the human estrogen receptor $\alpha$ ligand-binding domain (ER) and the selected ligands (L): 17$\beta$-estradiol (E2), 17$\alpha$-estradiol (17$\alpha$-E2), estriol (E3), genistein (GNT), diethylstilbestrol (DES ...
arxiv
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
Environmental Health Perspectives, 2016 Background: Humans are exposed to thousands of man-made chemicals in the environment. Some chemicals mimic natural endocrine hormones and, thus, have the potential to be endocrine disruptors.
K. Mansouri +40 more
semanticscholar +1 more source
Dual-path convolutional neural network using micro-FTIR imaging to predict breast cancer subtypes and biomarkers levels: estrogen receptor, progesterone receptor, HER2 and Ki67 [PDF]
arXiv, 2023 Breast cancer molecular subtypes classification plays an import role to sort patients with divergent prognosis. The biomarkers used are Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67. Based on these biomarkers expression levels, subtypes are classified as Luminal A (LA), Luminal B (LB), HER2 subtype, and Triple-Negative Breast ...
arxiv
The Expanding Complexity of Estrogen Receptor Signaling in the Cardiovascular System.
Circulation Research, 2016 Estrogen has important effects on cardiovascular function including regulation of vascular function, blood pressure, endothelial relaxation, and the development of hypertrophy and cardioprotection. However, the mechanisms by which estrogen mediates these
S. Menazza, E. Murphy
semanticscholar +1 more source
Journal of Leukocyte Biology, 2016 Estrogens are known modulators of monocyte/macrophage functions; however, the underlying mechanism has not been clearly defined. Recently, a number of estrogen receptor molecules and splice variants were identified that exert different and sometimes ...
V. Pelekanou +9 more
semanticscholar +1 more source
Sparse quadratic classification rules via linear dimension reduction [PDF]
Journal of Multivariate Analysis 2019, Vol. 169, 278-299, 2017 We consider the problem of high-dimensional classification between the two groups with unequal covariance matrices. Rather than estimating the full quadratic discriminant rule, we propose to perform simultaneous variable selection and linear dimension reduction on original data, with the subsequent application of quadratic discriminant analysis on the ...
arxiv +1 more source
Estrogen, Estrogen Receptor and Lung Cancer
International Journal of Molecular Sciences, 2017 Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway ...
L. Hsu, N. Chu, S. Kao
semanticscholar +1 more source
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
New England Journal of Medicine, 1994 BACKGROUND AND METHODS Mutations in the estrogen-receptor gene have been thought to be lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in the estrogen-receptor gene underwent studies of pituitary-gonadal function ...
Eric P. Smith +8 more
semanticscholar +1 more source
FMO Interaction Energy between 17$β$-Estradiol, 17$α$-Estradiol and Human Estrogen Receptor $α$ [PDF]
arXiv, 2020 The estrogen receptor is a nuclear hormone receptor activated by the natural steroid hormone 17$\beta$-estradiol (E2). Fragment molecular orbital (FMO) calculations were performed which allowed us to obtain the interaction energy ($E_{int}$) between E2, 17$\alpha$-estradiol (17$\alpha$-E2) and the human estrogen receptor $\alpha$ ligand-binding domain.
arxiv