Results 251 to 260 of about 262,665 (314)

Anti-Neoplastic Activity of Estrogen Receptor Beta in Chemoresistant Triple-Negative Breast Cancer. [PDF]

Cancers (Basel)
Wang X, Emch MJ, Goetz MP, Hawse JR.
europepmc   +1 more source

Dietary Berberine Reduced Oxido‐Inflammatory Stress in Rats' Livers and Kidneys, Supplemented from Prepuberty to Adulthood

ChemFoodChem, EarlyView.
Berberine (BER) demonstrates significant protective effects on the hepatorenal system in rats, mediated through various cellular and molecular mechanisms spanning from the prepubertal stage through adulthood. These mechanisms encompass antioxidant, anti‐inflammatory, and anti‐apoptotic activities, in addition to modulation of essential signalling ...
Solomon Owumi, Bayode Oluwawibe, Harieme Agbarogi, Moses T. Otunla, Uche Arunsi, Jesutosin O. Babalola, Chioma Irozuru, Chima Amadi, Ahmad Altayyar   +8 more
wiley   +1 more source

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM's regulatory scientific confidence framework. [PDF]

Front Toxicol
Ryman J, Becker RA.
europepmc   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

A novel solid phase synthesis of an estradiol derivative and preclinical evaluation for targeting estrogen-receptor positive breast cancer. [PDF]

Sci Rep
Okarvi SM.
europepmc   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Estrogen receptor β stimulation as a possible novel therapeutic target for cutaneous T-cell lymphoma. [PDF]

Blood Adv
Özistanbullu D, Wilhelm R, Reichenbach G, Doll M, Bahrami K, Zöller N, Schnütgen F, König A, Scheller T, Winkler L, Spahn P, Jäger M, Nicolay JP, Pfeilschifter J, Schilling B, Kaufmann R, Koch A, Kippenberger S, Kleemann J, Meissner M.   +19 more
europepmc   +1 more source

Dual Targeting Approach Using 4‐Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue

ChemMedChem, EarlyView.
The [F7,P34]‐pNPY based peptide‐drug conjugate targets the Y1 receptor and induces internalization. Once inside the cell, 4‐hydroxytamoxifen is cleaved from the peptide and is released into the cytosol, where it activates the estrogen receptor α. This dual‐targeting mechanism aims to promote body weight loss and offers a potential therapeutic strategy ...
Anna Kohler, Eva‐Maria Jülke, Luke C. Darveniza, Jan Stichel, Annette G. Beck‐Sickinger   +4 more
wiley   +1 more source

Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women. [PDF]

Nat Commun
Nierenberg JL, Adamson AW, Hu D, Huntsman S, Patrick C, Li M, Steele L, Tao S, Ding YC, Tong B, Shieh Y, Fejerman L, Gruber SB, Haiman CA, John EM, Kushi LH, Torres-Mejía G, Ricker C, Weitzel JN, Ziv E, Neuhausen SL.   +20 more
europepmc   +1 more source

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways. [PDF]

Front Mol Neurosci
Lee HJ, Bostick Z, Doherty J, Swanson TL, Kelly MJ, Quinn JF, Gray NE, Copenhaver PF.   +7 more
europepmc   +1 more source