Results 21 to 30 of about 2,368,340 (74)
Science Translational Medicine, 2015 Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer.
A. Bosch +27 more
semanticscholar +1 more source
Pharmacological Reviews, 2015 Estrogens are critical mediators of multiple and diverse physiologic effects throughout the body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and immune systems.
E. Prossnitz, J. B. Arterburn
semanticscholar +1 more source
Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent [PDF]
arXiv, 2023 Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production.
arxiv
Bayesian Variable Selection for Probit Mixed Models Applied to Gene Selection [PDF]
Bayesian Analysis 6, 2 (2011) 209-230, 2011 In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of observations and diversify the data, allowing a more reliable selection of genes relevant to the biological problem ...
arxiv +1 more source
Relative Binding Free Energy Calculations for Ligands with Diverse Scaffolds with the Alchemical Transfer Method [PDF]
arXiv, 2021 We present an extension of Alchemical Transfer Method (ATM) for the estimation of relative binding free energies of molecular complexes applicable to conventional as well as scaffold-hopping alchemical transformations. The method, named ATM-RBFE, implemented in the free and open-source OpenMM molecular simulation package, aims to provide a simpler and ...
arxiv
Genome-wide modelling of transcription kinetics reveals patterns of RNA production delays [PDF]
PNAS 112(42):13115-13120, 2015, 2015 Genes with similar transcriptional activation kinetics can display very different temporal mRNA profiles due to differences in transcription time, degradation rate and RNA processing kinetics. Recent studies have shown that a splicing-associated RNA production delay can be significant.
arxiv +1 more source
Journal of Medicinal Chemistry, 2015 Drugs that inhibit estrogen receptor alpha (ERα) or that block the production of estrogens remain frontline interventions in the treatment and management of breast cancer at all stages.
D. McDonnell, S. Wardell, J. Norris
semanticscholar +1 more source
Joint Stream: Malignant Region Learning for Breast Cancer Diagnosis [PDF]
Volume 99, January 2025, 106899Early diagnosis of breast cancer (BC) significantly contributes to reducing the mortality rate worldwide. The detection of different factors and biomarkers such as Estrogen receptor (ER), Progesterone receptor (PR), Human epidermal growth factor receptor 2 (HER2) gene, Histological grade (HG), Auxiliary lymph node (ALN) status, and Molecular subtype ...
arxiv +1 more source
Progesterone receptor modulates estrogen receptor-α action in breast cancer
Nature, 2015 Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its ...
Hisham Mohammed +23 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1993 Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development.
D. Lubahn +6 more
semanticscholar +1 more source