Results 101 to 110 of about 2,243,537 (271)

Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice

Environmental Health, 2006
Background Vinclozolin is a fungicide that has been reported to have anti-androgenic effects in rats. We have found that in utero exposure to natural or synthetic progesterones can induce hypospadias in mice, and that the synthetic progesterone ...
Baskin Laurence S, Agras Koray, Willingham Emily, Buckley Jill   +3 more
doaj   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Potent estrogen receptor β agonists with inhibitory activity in vitro, fail to suppress xenografts of endocrine-resistant cyclin-dependent kinase 4/6 inhibitor-resistant breast cancer cells

Frontiers in Oncology
ObjectiveSeventy percent of newly diagnosed breast cancers are estrogen receptor-α positive and HER2/neu negative. First-line treatments incorporate endocrine therapy and cyclin-dependent kinase 4/6 inhibitors.
Lynn M. Marcho, Christopher C. Coss, Christopher C. Coss, Menglin Xu, Jharna Datta, Jasmine M. Manouchehri, Mathew A. Cherian   +6 more
doaj   +1 more source

Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer

Cell Reports, 2018
Summary: Steroid hormone receptors are simultaneously active in many tissues and are capable of altering each other’s function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus, and their ligands have opposing effects
Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, Adriana C. Rodriguez, Aliyah Almomen, Kristofer C. Berrett, Alexis N. Trujillo, Katrin P. Guillen, Bryan E. Welm, Elke A. Jarboe, Margit M. Janat-Amsbury, Jason Gertz   +10 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Transcriptomic Profiling Reveals 17β‐Estradiol Treatment Represses Ubiquitin‐Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice

Journal of Cachexia, Sarcopenia and Muscle
Background With a decline of 17β‐estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the ...
Georgios Kararigas, Mara C. Ebeling, Gengyun Le, Shaojuan Lai, Chunmei Cui, Qinghua Cui, Dawn A. Lowe   +6 more
doaj   +1 more source

Single-cell states in the estrogen response of breast cancer cell lines [PDF]

, 2014
Estrogen responsive breast cancer cell lines have been extensively studied to characterize transcriptional patterns in hormone-responsive tumors. Nevertheless, due to current technological limitations, genome-wide studies have typically been limited to ...
Andrea Gamba, Nassa, Giovanni, Roberto Amendola, Mario Nicodemi (81682), Sach Mukherjee (19432), Chris J Oates, Francesco Paolo Casale (526999), Nicodemi, M, Weisz, Alessandro, Gamba, A, Jonathan, W., Alessandro Weisz (90872), Alessandro Weisz, Giorgio Giurato (527000), Giorgio Giurato, Gamba, Andrea, Cora', Davide, Chris J. Oates, Gamba, Andrea Antonio, Armond, Jonathan W., Weisz, A, Amendola, Roberto, Mukherjee, Sach, Casale, Francesco Paolo, Oates, Chris J., Jonathan W. Armond, Mario Nicodemi, Oates, CJ, Giovanni Nassa, Davide Corá, Nassa, G, Corá, Davide, Ro Weisz, Mukherjee, S, Giovanni Nassa (527001), Chris J. Oates (527003), Francesco Paolo Casale, Giurato, Giorgio, Andrea Gamba (181217), Nicodemi, Mario, Sach Mukherjee, Davide Cor?, Giurato, G, Corá, D, Chris, J., Jonathan W Armond, Davide Corá (5649682), Armond, JW, Jonathan W. Armond (527002), Casale, FP   +49 more
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro

, 2007
Withdrawal of estrogen represents the primary factor determining post menopausal bone loss and has been associated with negative indicators of bone quality including the apoptotic death of osteocytes in vivo. While hormone replacement therapy in the form
Noble, Brendon, Collins, Frances, Huber, Christene, Mann, Val, Kogianni, Giolanta   +4 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source