Results 181 to 190 of about 289,593 (270)

Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias. [PDF]

J Clin Invest
Potluri T, You T, Yin P, Coon J, Stulberg JJ, Dai Y, Escobar DJ, Lieber RL, Zhao H, Bulun SE.   +9 more
europepmc   +1 more source

TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth. [PDF]

Cancers (Basel), 2023
Zhang Y, Fang X, Wang J, Nie D.
europepmc   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice. [PDF]

Bone Res
Jiang Y, Horkeby K, Henning P, Wu J, Nilsson KH, Lawenius L, Movérare-Skrtic S, Gupta P, Engdahl C, Koskela A, Tuukkanen J, Li L, Ohlsson C, Lagerquist MK.   +13 more
europepmc   +1 more source

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer. [PDF]

Cancer Sci, 2023
Cao J, Wang X, Wang S, Chen Z, Tang J.
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor α. [PDF]

ACS Pharmacol Transl Sci
Hou Y, Nwachukwu JC, Carlson K, Kim SH, Angle S, Jacobsen EN, Woods T, Mateus SL, Fanning SW, Ziegler Y, Katzenellenbogen BS, Nettles KW, Katzenellenbogen JA.   +12 more
europepmc   +1 more source

Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α. [PDF]

Bone Res, 2023
Wang N, Lu Y, Rothrauff BB, Zheng A, Lamb A, Yan Y, Lipa KE, Lei G, Lin H.   +8 more
europepmc   +1 more source

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source

A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for Cell-Membrane Permeable Inhibitors for the Interaction Between Estrogen Receptor α and Coactivator SRC1. [PDF]

Chembiochem
Fujiwara D, Inaura S, Tanaka Y, Ito-Harashima S, Yamaguchi-Nomoto A, Kawanishi M, Yagi T, Nakase I, Fujii I.   +8 more
europepmc   +1 more source