Results 161 to 170 of about 2,243,537 (271)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress. [PDF]

Cartilage
Takesue S, Hirose N, Yanoshita M, Nishiyama S, Tsuboi E, Kubo N, Kita D, Asakawa Y, Tanimoto K.   +8 more
europepmc   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

The role and mechanism of estrogen/estrogen receptor α in sexual identity determination of chicken somatic cells. [PDF]

Poult Sci
Jin Z, Lin X, Wu X, Wen K, Li S, Omara A, Ge J, Gong H, Zhao M, Zhang J, Gong D, Liu L, Geng T.   +12 more
europepmc   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE^-/- mice via regulating estrogen receptor α. [PDF]

Chin Med
Chen L, Shi JH, Ma XJ, Chai H, Wei KK, Yang Z, Tan Y, Huang HB, Shi DZ, Qu H.   +9 more
europepmc   +1 more source

Urogenital Infection Risk Associated With SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Type 2 Diabetes and Chronic Kidney Disease: A Nationwide Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Although sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) are recommended for patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), concerns regarding urogenital infections persist. Therefore, we evaluated the risk of urinary tract infection (UTI) and genital tract infection (GTI) after SGLT2i initiation in this population ...
Young‐Mi Ah, Junsung Nam, Jung Wook Youn, Yun Mi Yu, Soyoung Kang   +4 more
wiley   +1 more source

Correction: Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels

PLoS ONE, 2014
doaj   +3 more sources

Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice. [PDF]

J Endocrinol
Jiang Y, Horkeby K, Henning P, Nilsson KH, Wu J, Li L, Movérare-Skrtic S, Ohlsson C, Lagerquist MK.   +8 more
europepmc   +1 more source

Roles of estrogen receptor α in endometrial carcinoma (Review). [PDF]

Oncol Lett, 2023
Ge Y, Ni X, Li J, Ye M, Jin X.
europepmc   +1 more source