Results 171 to 180 of about 2,198,676 (277)

Liver X receptors and estrogen receptor β, two players in a rare subtype of NSCLC. [PDF]

Int J Biol Sci, 2023
Wu W, Sarhadi M, Song X, Xue J, Dai Y, Gustafsson JA.   +5 more
europepmc   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Estrogen receptor β regulates sex-dependent airway mechanics and inflammation in a murine model of allergen exposure. [PDF]

Physiol Rep
Ekpruke CD, Rousselle D, Babayev M, Borges-Sosa O, Alford R, Dinwiddie L, Merritt DM, Hemmerich CM, Rusch DB, Bradley S, Retzner ML, Parker E, Silveyra P.   +12 more
europepmc   +1 more source

Significant Association of Estrogen Receptor-β Isoforms and Coactivators in Breast Cancer Subtypes. [PDF]

Curr Issues Mol Biol, 2023
Choi Y, Pollack S.
europepmc   +1 more source

Longitudinal Echocardiographic Surveillance of Aortic Dilation in a Phenotype‐Enriched Turner Syndrome Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome (TS) is associated with thoracic aortopathy and increased risk for aortic dissection, yet the natural history of aortic dilation is not well understood. We performed a retrospective longitudinal study of individuals with TS who participated in the TS Society of the United States Healthy Heart Project between 2003 and 2023 ...
Dylan Doerner, Matthew R. Johnson, Sara Mansoorshahi, Rakesh Kathiresan, Katelyn Abel, Jonathan G. You, Emilio Quezada, Siddharth K. Prakash   +7 more
wiley   +1 more source

Rethinking estrogen receptor β in EAOC: a synergistic modulator in a genomically informed landscape. [PDF]

J Ovarian Res
Luo L, Dai W, Cao N, Ye M.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells

, 2015
Estrogen receptor signaling is involved in the etiology of multiple diseases including the development and progression of Type 2 Diabetes Mellitus, T2DM.
Dover, Ellen Nicole
core  

Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis. [PDF]

J Clin Invest
Zhu Y, Li G, Guo Y, He Y, Zhang W, Gao L, Zhang J, Guo P, Lin H, Zhang W, Wei Z, Xia Y, Dai Y.   +12 more
europepmc   +1 more source