Results 131 to 140 of about 90,675 (307)

Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-alpha in female hepatocellular carcinoma

, 2017
The estrogen pathway has long been implicated as a tumor protector in female hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Our previous study identified that estrogen receptor alpha (ER) protein is downregulated in 60% of female HCC ...
陳定信;葉坤輝;葉秀慧;陳培哲;陳祈玲, Li, Chiao-Ling;Yeh, Kun-Huei;Liu, Wan-Hsin;Chen, Chi-Ling;Chen, Ding-Shinn;Chen, Pei-Jer;Yeh, Shiou-Hwei   +1 more
core   +1 more source

Estrogen Receptor Alpha immunoreactivity

, 2016
The file contains averaged cell counts for estrogen receptor alpha immunoreactivity in males and females of four species of Peromyscus. Two that are socially monogamous, P. californicus and P. polionotus and two polygynous, P.
Bruce S. Cushing (367604), Cushing, Bruce S.   +1 more
core   +1 more source

Cortical bone distribution in the human mandibular symphysis: Ontogenic and morphometric approaches in archeological context

The Anatomical Record, EarlyView.
Abstract The human mandibular symphysis concentrates multiaxial loads during function and remodels throughout growth, but the precise mechanisms underlying cortical bone shape during growth remain relatively unexplored. Approaches based solely on thickness or external cortical contours provide only partial insights and do not capture the functional ...
Ana Ribeiro, Elsa Garot, Christine Couture, Pierre‐Hadrien Decaup   +3 more
wiley   +1 more source

A Regulatory “miRcircuitry” Involving miR221&222 and ERα Determines ERα Status of Breast Cancer Cells

, 2009
Estrogen Receptor α (ERα) is the most important diagnostic and prognostic factor in breast cancer. Several lines of evidence have suggested that ERα-negative breast tumors, highly aggressive and non-responsive to hormonal therapy, arise from ERα ...
Di Leva, Gianpiero
core  

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Key regulator of cellular metabolism, estrogen-related receptor α, a new therapeutic target in endocrine-related gynecological tumor

, 2018
GuiFen Liu,1 PengMing Sun,1,2 BinHua Dong,1 Jalid Sehouli3 1Laboratory of Gynaecologic Oncology, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, 350001 Fuzhou, Fujian, People’s Republic ...
Sun P, Liu G, Dong B, Sehouli J
core  

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

Regulation of estrogen responsive genes by human Estrogen Receptor alpha [PDF]

, 2007
In women, breast cancer is the most common cancer and accounts for most cancer deaths. The molecular mechanisms underlying this pathology are diverse and contribute to the complexity of the disease. Early diagnosis and detailed molecular characterization of tumours significantly increase the prognosis for the patients. A limited number of breast cancer
openaire   +1 more source

Cardiovascular roles of estrogen receptors: insights gained from knockout models

, 2003
The effects of estrogen are mediated through two functionally distinct receptors, estrogen receptor alpha (ER- alpha ), and estrogen receptor beta (ER- beta ), both of which are expressed in the cardiovascular system.
Gustafsson, J-A, Dahlman-Wright, K,, Otsuki, M   +2 more
core   +1 more source