Results 151 to 160 of about 82,886 (305)

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Targeting estrogen receptor alpha in breast cancer for novel therapies resistance mechanisms and future directions. [PDF]

Discov Oncol
Wu BX, Wu HT, Lan YZ, Chen WJ, Yu XN, Liu JW, Liu J.   +6 more
europepmc   +1 more source

Supplemental Table 4 from Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–Mutant Endometrial Cancer [PDF]

Zannel Blanchard, Craig M. Rush, Spencer Arnesen, Jeffery M. Vahrenkamp, Adriana C. Rodriguez, Elke A. Jarboe, Callie Brown, Matthew E.K. Chang, Mark R. Flory, Hisham Mohammed, Katarzyna Modzelewska, David H. Lum, Jason Gertz   +12 more
openalex   +1 more source

Characterization of Flavonoids with Potent and Subtype-Selective Actions on Estrogen Receptors Alpha and Beta

, 2023
Michael J. Bolt, Jessica Oceguera, Pankaj K. Singh, Kazem Safari, Derek H. Abbott, Kaley A. Neugebauer, Maureen G. Mancini, Daniel A. Gorelick, Fabio Stossi, Michael A. Mancini   +9 more
openalex   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Inhibition of estrogen receptor alpha stabilizes regulatory T cell function in autoimmune hepatitis. [PDF]

JHEP Rep
Zhang L, Gromova B, Nguyen DH, Cagle C, Gomes GS, Li W, Gao L, Zhang W, Graham JJ, Wang N, Kalbasi A, Csizmadia E, Wei A, Cassavaugh J, Bonder A, Patwardhan V, Jiang S, Kota SK, Longhi MS.   +18 more
europepmc   +1 more source

Investigation of Estrogen Receptor Alpha, Beta Adrenergic Receptor and COMT as Candidate Genes for Tako-Tsubo Cardiomyopathy [PDF]

, 2012
Gemma A. Figtree, Richard D. Bagnall, Irfan Abdulla, W. Yan, S. Bucholz, Rachael Cordina, Colette O’Neill, John D. Horowitz, C. Semsarian, Michael P. Ward   +9 more
openalex   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha. [PDF]

Nat Commun
Jiang S, Liu K, Jiang T, Li H, Wei X, Wan X, Zhong C, Gong R, Chen Z, Zou C, Zhang Q, Cheng Y, Cao D.   +12 more
europepmc   +1 more source