Results 11 to 20 of about 82,886 (305)

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Estrogen Receptor Alpha Gene Polymorphisms and Stroke [PDF]

Cerebrovascular Diseases, 2008
lated to stroke [8] . In addition, using diplotype analysis we found that female patients less frequently had the CCGG diplotype compared to men and that female patients with TTAA diplotype tended to have a higher stroke incidence compared to females with other diplotypes [4] . Since both the studies by Strand et al.
Markoula, S., Lazaros, L., Xita, N., Giannopoulos, S., Georgiou, I., Kyritsis, A. P.   +5 more
openaire   +3 more sources

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer [PDF]

Breast Cancer Research, 2004
Current hormonal therapies have benefited millions of patients with breast cancer. Their success, however, is often temporary and limited to a subset of patients whose tumors express estrogen receptor alpha (ER). The therapies are entirely ineffective in ER-negative disease. Recent studies suggest that there are many biological pathways and alterations
Allred, D Craig, Brown, Powel, Medina, Daniel   +2 more
openaire   +4 more sources

ESRRA (estrogen-related receptor alpha) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ESRRA (estrogen-related receptor alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Stein, Kunder R, McDonnell, DP
openaire   +2 more sources

Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]

Seminars in Reproductive Medicine, 2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E., Cheng, You-Hong, Pavone, Mary Ellen, Xue, Qing, Attar, Erkut, Trukhacheva, Elena, Tokunaga, Hideki, Utsunomiya, Hiroki, Yin, Ping, Luo, Xia, Lin, Zhihong, Imir, Gonca, Thung, Stephen, Su, Emily J., Kim, J. Julie   +14 more
openaire   +4 more sources

Whole-genome cartography of estrogen receptor alpha binding sites. [PDF]

PLoS Genetics, 2007
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells.
Chin-Yo Lin, Vinsensius B Vega, Jane S Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D Miller, Edwin Cheung, Benita S Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T Liu   +22 more
doaj   +1 more source

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire   +2 more sources

Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer

Acta Biochimica Indonesiana, 2021
Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer.
Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari   +4 more
doaj   +1 more source

UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA

Jurnal Farmasi Sains dan Komunitas, 2015
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan, Enade Perdana Istyastono   +1 more
doaj   +1 more source