Results 191 to 200 of about 80,501 (258)

Development and Validation of a Consensus Machine Learning–Derived Signature to Predict Survival and Treatment Benefits in Breast Cancer

Medicine Advances, EarlyView.
The consensus machine learning–derived prognostic signature (CMDPS) was developed by integrating 10 independent breast cancer cohorts and 76 algorithm combinations, which identified 19 robust survival‐associated genes. The CMDPS demonstrated superior prognostic performance compared to clinical features and 62 published transcriptome signatures ...
Guangyang Cheng, Zhan Wang, Fu Peng, Shuai Yang, Yudi Xu, Hongzhuo Qin, Run Shi, Zhaokai Zhou   +7 more
wiley   +1 more source

Investigating Lasofoxifene Efficacy Against the Y537S + F404V Double-Mutant Estrogen Receptor Alpha Using Molecular Dynamics Simulations. [PDF]

Bioinform Biol Insights
Bouricha EM, Hakmi M.
europepmc   +1 more source

Urinary Cytokines in Predicting Intradetrusor Onabotulinumtoxin‐A Response

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose The impact of asymptomatic bacteriuria and inflammation on response to Onabotulinumtoxin‐A for overactive bladder is poorly understood. This work compares baseline differences in asymptomatic bacteriuria status and urinary inflammatory markers between women who respond to Onabotulinumtoxin‐A and those who do not.
Marina Guirguis Hanna, Ashti M. Shah, Wuqi Li, Ervin Sejdic, Megan Bradley, Stephanie W. Zuo, Amanda M. Artsen   +6 more
wiley   +1 more source

Rational evolution for altering the ligand preference of estrogen receptor alpha. [PDF]

Protein Sci
Eerlings R, Gupta P, Lee XY, Nguyen T, El Kharraz S, Handle F, Smeets E, Moris L, Devlies W, Vandewinkel B, Thiry I, Ta DT, Gorkovskiy A, Voordeckers K, Henckaerts E, Pinheiro VB, Claessens F, Verstrepen KJ, Voet A, Helsen C.   +19 more
europepmc   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

Obesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu, Hao Dai, Huilin Tang, William T. Donahoo, Thomas J. George, Ramon C. Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D. Licht, John M. Allen, Kelvin P. Lee, Jingchuan Guo, Jiang Bian   +13 more
wiley   +1 more source

Female mice lacking membrane estrogen receptor alpha display impairments in spatial memory. [PDF]

Horm Behav
DeLarge AF, Stanley MJ, Daniel JM.
europepmc   +1 more source

Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance

Obesity, EarlyView.
ABSTRACT Objective Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT‐derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang‐Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep   +10 more
wiley   +1 more source

Salivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha. [PDF]

Cell Mol Biol Lett
Mao T, Wei W, Chen B, Chen Y, Liang S, Chen G, Liu Z, Wu X, Wu L, Li X, Watanabe N, Mayo KH, Pathak JL, Li J.   +13 more
europepmc   +1 more source

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Verhoef CJA, Crowe C, Nakasone MA, DeLaCuadra-Basté A, Harzing T, Span NAS, Sathe G, Iso K, Ottmann C, Brunsveld L, Ciulli A, Cossar PJ.   +11 more
europepmc   +1 more source