Results 261 to 270 of about 303,397 (337)

Association of Inflammation and Immune Cell Infiltration with Estrogen Receptor Alpha in an Estrogen and Ionizing Radiation-Induced Breast Cancer Model. [PDF]

Int J Mol Sci
Koning T, Calaf GM.
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Investigation of a Radio-Iodinated Alpha-Mangostin for Targeting Estrogen Receptor Alpha (ERα) in Breast Cancer: In Silico Design, Synthesis, and Biological Evaluation. [PDF]

Drug Des Devel Ther
Muchtaridi M, Nurhidayah W, Fakih TM, Kannaka K, Suzuki H, Subroto T, Uehara T.   +6 more
europepmc   +1 more source

Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women

, 2003
Lars Westberg, Jonas Melke, Mikael Landén, Staffan Nilsson, Fariba Baghaei, Roland Rosmond, Maria Jansson, G. Holm, Per Björntorp, Elias Eriksson   +9 more
openalex   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Abnormal Serum Lipid Levels and Ocular Metabolic Mediators in Adult‐Onset Myopia: A Cohort Study

Medicine Advances, EarlyView.
Elevated levels of “good cholesterol” markers apolipoprotein A (APOA) and high‐density lipoprotein cholesterol (HDL‐C) were prospectively associated with an increased risk of developing adult‐onset myopia, whereas higher levels of “bad cholesterol” markers apolipoprotein B (APOB) and low‐density lipoprotein cholesterol (LDL‐C) were associated with a ...
Feipeng Jiang, Dawen Wu, Xi Wang, Jier Ma, Xiaohang Chen, Yun Zhang, Chunyan Lei, Jianjun Ren, Longqian Liu, Meixia Zhang   +9 more
wiley   +1 more source

Randomized Controlled Trial: Effects of a Bitter‐Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects

Molecular Nutrition &Food Research, EarlyView.
Two pea protein hydrolysates (PPHs) reduced hunger by targeting different mechanisms: PPH1 produced a faster response in satiety and hunger hormone levels in the blood, while PPH2 had a stronger impact on gastric emptying. These effects are likely due to the differing degrees of hydrolysis between the two PPHs.
Katrin Gradl, Sonja Sterneder, Kristin Kahlenberg, Beate Brandl, Thomas Skurk, Veronika Somoza   +5 more
wiley   +1 more source

Endosomal recycling inhibitors downregulate estrogen receptor-alpha and synergise with endocrine therapies. [PDF]

Breast Cancer Res Treat
Fletcher KA, Alkurashi MH, Lindsay AJ.
europepmc   +1 more source

Effects of Genistein on Inflammasome Induced Pancreatic β‐Cell Apoptosis by Dexamethasone

Molecular Nutrition &Food Research, EarlyView.
The possible mechanism of genistein‐mediated protection against dexamethasone‐induced pancreatic β‐cell apoptosis. Genistein decreases the activation of IRE‐1α, resulting in the reduction of sXBP1, JNK, TXNIP, NLRP3, and IL‐1β expression. Genistein inhibits dexamethasone‐induced pancreatic β‐cell apoptosis.
Nattinee Jitprawet, Jatuporn Sujjitjoon, Petcharee Maneethorn, Namoiy Semprasert, Suwattanee Kooptiwut   +4 more
wiley   +1 more source

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory. [PDF]

J Neurosci
Mitchnick KA, Nicholson K, Wideman C, Jardine K, Jamieson-Williams R, Creighton SD, Lacoursiere A, Milite C, Castellano S, Sbardella G, MacLusky NJ, Choleris E, Winters BD.   +12 more
europepmc   +1 more source