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Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice.

open access: yesJ Appl Physiol (1985)
Sullivan BP   +6 more
europepmc   +1 more source
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Transcriptional Suppression of the Estrogen Receptor by Truncated Estrogen Receptor-Alpha

Hormone and Metabolic Research, 2002
The estrogen receptor (ER) is composed of six major functional domains - the A/B domain as the activation function 1 domain, domain C as the DNA-binding domain, domain D as a hinge domain, and domain E/F as the ligand-dependent transcriptional domains. A novel protein (designated as SRB-RGS) that interacted with domains C and D of ER alpha (ER alpha C ...
M, Ikeda   +4 more
openaire   +2 more sources

Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation

Urologic Oncology: Seminars and Original Investigations, 2020
Estrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive.
Bernardo, Carina   +13 more
openaire   +3 more sources

The multifunctional estrogen receptor-alpha F domain

Endocrine, 2008
The members of the nuclear receptor superfamily act as transcriptional regulatory factors and exhibit a multidomain structure characterized as domains A-E/F. This review focuses on a small, relatively understudied region at the extreme carboxy-terminus of the estrogen receptor (ER) alpha, the F domain.
Debra F, Skafar, Changqing, Zhao
openaire   +2 more sources

Photoperiod affects estrogen receptor alpha, estrogen receptor beta and aggressive behavior.

The European journal of neuroscience, 2007
Estrogens have important effects on male and female social behavior. Despite growing knowledge of the anatomy and behavioral effects of the two predominant estrogen receptor subtypes in mammals (ERalpha and ERbeta), relatively little is known about how these receptors respond to salient environmental stimuli. Many seasonally breeding species respond to
Brian C, Trainor   +2 more
openaire   +2 more sources

Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner

Biochemical and Biophysical Research Communications, 2009
Hypoxia activates and degrades estrogen receptor alpha (ERalpha) in human breast cancer cells, which may play an important role in the development and progression of breast cancer. In this study, the synergistic effects of estrogen (E(2)) and hypoxia on ERalpha-mediated transactivation and ERalpha degradation were investigated.
Jinhyung Michael, Yi   +3 more
openaire   +2 more sources

p33ING1b and estrogen receptor (ER) α

Breast Cancer, 2004
The ING1 gene was originally cloned as a candidate tumor suppressor of human breast cancer, and recent studies suggest that ING1 proteins are involved in chromatin remodeling functions via physical association with both histone acetyltransferases (HATs) and histone deacetylases (HDACs). Both CREB binding protein (CBP) and the related p300 proteins show
Tatsuya, Toyama, Hirotaka, Iwase
openaire   +2 more sources

Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice

Neurobiology of Aging, 2016
Estrogens are known to exert neuroprotective and immuneomodulatory effects after stroke. However, at present, little is known about the role of estrogens and its receptors in postischemic inflammation after menopause. Here, we provide important in vivo evidence of a distinct shift in microglial phenotypes in the model of postmenopause brain.
Pierre, Cordeau   +3 more
openaire   +2 more sources

S-palmitoylation modulates human estrogen receptor-α functions

Biochemical and Biophysical Research Communications, 2004
17beta-Estradiol (E2)-induced rapid functions (from seconds to minutes) can be attributed to a fraction of nuclear estrogen receptor-alpha (ERalpha) localized at the plasma membrane. As a potential mechanism, we postulated that S-palmitoylation of the Cys447 residue may explain the ability of ERalpha to associate to plasma membrane making possible E2 ...
ACCONCIA, FILIPPO   +4 more
openaire   +4 more sources

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