Results 21 to 30 of about 80,501 (258)

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer [PDF]

Breast Cancer Research, 2004
Current hormonal therapies have benefited millions of patients with breast cancer. Their success, however, is often temporary and limited to a subset of patients whose tumors express estrogen receptor alpha (ER). The therapies are entirely ineffective in ER-negative disease. Recent studies suggest that there are many biological pathways and alterations
Allred, D Craig, Brown, Powel, Medina, Daniel   +2 more
openaire   +4 more sources

ESRRA (estrogen-related receptor alpha) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ESRRA (estrogen-related receptor alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Stein, Kunder R, McDonnell, DP
openaire   +2 more sources

Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]

Seminars in Reproductive Medicine, 2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E., Cheng, You-Hong, Pavone, Mary Ellen, Xue, Qing, Attar, Erkut, Trukhacheva, Elena, Tokunaga, Hideki, Utsunomiya, Hiroki, Yin, Ping, Luo, Xia, Lin, Zhihong, Imir, Gonca, Thung, Stephen, Su, Emily J., Kim, J. Julie   +14 more
openaire   +4 more sources

MATH: A Deep Learning Approach in QSAR for Estrogen Receptor Alpha Inhibitors

Molecules, 2023
Breast cancer ranks as the second leading cause of death among women, but early screening and self-awareness can help prevent it. Hormone therapy drugs that target estrogen levels offer potential treatments.
Rizki Triyani Pusparini, Adila Alfa Krisnadhi, Firdayani   +2 more
doaj   +1 more source

Whole-genome cartography of estrogen receptor alpha binding sites. [PDF]

PLoS Genetics, 2007
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells.
Chin-Yo Lin, Vinsensius B Vega, Jane S Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D Miller, Edwin Cheung, Benita S Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T Liu   +22 more
doaj   +1 more source

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire   +2 more sources

Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer

Acta Biochimica Indonesiana, 2021
Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer.
Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari   +4 more
doaj   +1 more source

UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA

Jurnal Farmasi Sains dan Komunitas, 2015
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan, Enade Perdana Istyastono   +1 more
doaj   +1 more source

Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer [PDF]

Breast Cancer Research, 2000
Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone replacement, and for fertility regulation. Certain compounds that act through the estrogen receptor (ER), now referred to as selective estrogen ...
S Katzenellenbogen, Benita, A Katzenellenbogen, John   +1 more
openaire   +2 more sources

In Silico Evaluation of Alpha Mangostin and its Derivatives as a potential Anti-Cancer Agents [PDF]

BIO Web of Conferences
Alpha-Mangostin, a natural xanthone from Garcinia mangostana, and its structurally optimized derivatives were evaluated as anticancer agents targeting estrogen receptor proteins linked to breast cancer: Estrogen Receptor Alpha(3ERT), Estrogen Receptor ...
V Harini Rakshitha, P Maheshwari, P Yamini Devi, Prabhu Puniethaa   +3 more
doaj   +1 more source