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Estrogen Receptor Alpha Gene Polymorphisms and Stroke [PDF]

Cerebrovascular Diseases, 2008
lated to stroke [8] . In addition, using diplotype analysis we found that female patients less frequently had the CCGG diplotype compared to men and that female patients with TTAA diplotype tended to have a higher stroke incidence compared to females with other diplotypes [4] . Since both the studies by Strand et al.
Markoula, S., Lazaros, L., Xita, N., Giannopoulos, S., Georgiou, I., Kyritsis, A. P.   +5 more
openaire   +4 more sources

TRIM33 Is a Co-Regulator of Estrogen Receptor Alpha. [PDF]

Cancers (Basel)
Estrogen receptor alpha (ER)-positive breast cancer is responsible for over 60% of breast cancer cases in the U.S. Among patients diagnosed with early-stage ER+ disease, 1/3 will experience recurrence despite treatment with adjuvant endocrine therapy. ER is a nuclear hormone receptor responsible for estrogen-driven tumor growth.
Romo BA, Karakyriakou B, Cressey L, Brauer BL, Yang H, Warren A, Johnson AL, Kettenbach AN, Miller TW.   +8 more
europepmc   +3 more sources

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

International Journal of Molecular Sciences, 2020
The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes ...
Madhulika Tripathi, P. Yen, B. Singh
semanticscholar   +1 more source

ESRRA (estrogen-related receptor alpha) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ESRRA (estrogen-related receptor alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Stein, Kunder R, McDonnell, DP
openaire   +2 more sources

Whole-genome cartography of estrogen receptor alpha binding sites. [PDF]

PLoS Genetics, 2007
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells.
Chin-Yo Lin, Vinsensius B Vega, Jane S Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D Miller, Edwin Cheung, Benita S Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T Liu   +22 more
doaj   +1 more source

Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer

Acta Biochimica Indonesiana, 2021
Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer.
Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari   +4 more
doaj   +1 more source

UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA

Jurnal Farmasi Sains dan Komunitas, 2015
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan, Enade Perdana Istyastono   +1 more
doaj   +1 more source

Computer-Aided Ligand Discovery for Estrogen Receptor Alpha [PDF]

International Journal of Molecular Sciences, 2020
Breast cancer (BCa) is one of the most predominantly diagnosed cancers in women. Notably, 70% of BCa diagnoses are Estrogen Receptor α positive (ERα+) making it a critical therapeutic target. With that, the two subtypes of ER, ERα and ERβ, have contrasting effects on BCa cells.
Divya Bafna, Fuqiang Ban, Kriti Singh, Paul S. Rennie, Artem Cherkasov   +4 more
openaire   +2 more sources

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. [PDF]

PLoS ONE, 2009
While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones.
Aaron W James, Alexander A Theologis, Samantha A Brugmann, Yue Xu, Antoine L Carre, Philipp Leucht, Katherine Hamilton, Kenneth S Korach, Michael T Longaker   +8 more
doaj   +1 more source

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

eLife, 2016
Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies.
S. Fanning, C. Mayne, V. Dharmarajan, K. Carlson, Teresa A. Martin, S. Novick, Weiyi Toy, B. Green, S. Panchamukhi, B. Katzenellenbogen, E. Tajkhorshid, P. Griffin, Yang Shen, S. Chandarlapaty, J. Katzenellenbogen, G. Greene   +15 more
semanticscholar   +1 more source