Results 21 to 30 of about 121,912 (288)

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Genome Biology, 2019
Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data.
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz   +6 more
doaj   +1 more source

TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression

Cell Communication and Signaling, 2022
Background Breast cancer is the most common cancer in women worldwide. More than 70% of breast cancers are estrogen receptor (ER) alpha positive. Compared with ER alpha-negative breast cancer, which is more aggressive and has a shorter survival time, ER ...
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang   +17 more
doaj   +1 more source

Steroid-Functionalized Titanocenes: Docking Studies with Estrogen Receptor Alpha

Inorganics, 2016
Estrogen receptor alpha (ERα) is a transcription factor that is activated by hormones, with 17β-estradiol being its most active agonist endogenous ligand. ERα is also activated or inactivated by exogenous ligands. ER is overexpressed in hormone-dependent
Li Ming Gao, Wilson Maldonado, Xiomara Narváez-Pita, José A. Carmona-Negrón, Jesus Olivero-Verbel, Enrique Meléndez   +5 more
doaj   +1 more source

FMO Study of the Interaction Energy between Human Estrogen Receptor $α$ and Selected Ligands [PDF]

arXiv, 2022
Fragment molecular orbital (FMO) calculations were performed in aqueous media which allowed us to obtain the interaction energy between the human estrogen receptor $\alpha$ ligand-binding domain (ER) and the selected ligands (L): 17$\beta$-estradiol (E2), 17$\alpha$-estradiol (17$\alpha$-E2), estriol (E3), genistein (GNT), diethylstilbestrol (DES ...
arxiv  

aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.

PLoS ONE, 2014
In this study we describe the reproductive phenotypes of a novel mouse model in which Cre-mediated deletion of ERα is regulated by the aP2 (fatty acid binding protein 4) promoter.
Per Antonson, Marko Matic, Neil Portwood, Raoul V Kuiper, Galyna Bryzgalova, Hui Gao, Sara H Windahl, Patricia Humire, Claes Ohlsson, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. [PDF]

PLoS ONE, 2013
An increasing body of evidence now links estrogenic signalling with the metabolic syndrome (MS). Despite the beneficial estrogenic effects in reversing some of the MS symptoms, the underlying mechanisms remain largely undiscovered.
Marko Matic, Galyna Bryzgalova, Hui Gao, Per Antonson, Patricia Humire, Yoko Omoto, Neil Portwood, Camilla Pramfalk, Suad Efendic, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
wiley   +1 more source

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Advanced Biomedical Research, 2017
Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani   +2 more
doaj   +1 more source

Contrast‐enhanced micro‐computed tomography of compartment and time‐dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis

The Anatomical Record, Volume 306, Issue 1, Page 92-109, January 2023., 2023
Abstract A lack of understanding of the mechanisms underlying osteoarthritis (OA) progression limits the development of effective long‐term treatments. Quantitatively tracking spatiotemporal patterns of cartilage and bone degeneration is critical for assessment of more appropriately targeted OA therapies.
Deva D. Chan, Maleeha Mashiatulla, Jun Li, Ryan D. Ross, Meghana Pendyala, Amit Patwa, Mark W. Grinstaff, Anna Plaas, D. Rick Sumner   +8 more
wiley   +1 more source

Relative Binding Free Energy Calculations for Ligands with Diverse Scaffolds with the Alchemical Transfer Method [PDF]

arXiv, 2021
We present an extension of Alchemical Transfer Method (ATM) for the estimation of relative binding free energies of molecular complexes applicable to conventional as well as scaffold-hopping alchemical transformations. The method, named ATM-RBFE, implemented in the free and open-source OpenMM molecular simulation package, aims to provide a simpler and ...
arxiv