Results 31 to 40 of about 82,886 (305)

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Genome Biology, 2019
Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data.
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz   +6 more
doaj   +1 more source

Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice

Nature Communications, 2022
Estrogen secreted by the ovary controls how the brain drives pulsatile reproductive hormone secretion. The authors show that in mice, estrogen receptor alpha within a specific population of hypothalamic kisspeptin neurons is the principal pathway through
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison   +8 more
doaj   +1 more source

aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.

PLoS ONE, 2014
In this study we describe the reproductive phenotypes of a novel mouse model in which Cre-mediated deletion of ERα is regulated by the aP2 (fatty acid binding protein 4) promoter.
Per Antonson, Marko Matic, Neil Portwood, Raoul V Kuiper, Galyna Bryzgalova, Hui Gao, Sara H Windahl, Patricia Humire, Claes Ohlsson, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression

Cell Communication and Signaling, 2022
Background Breast cancer is the most common cancer in women worldwide. More than 70% of breast cancers are estrogen receptor (ER) alpha positive. Compared with ER alpha-negative breast cancer, which is more aggressive and has a shorter survival time, ER ...
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang   +17 more
doaj   +1 more source

Steroid-Functionalized Titanocenes: Docking Studies with Estrogen Receptor Alpha

Inorganics, 2016
Estrogen receptor alpha (ERα) is a transcription factor that is activated by hormones, with 17β-estradiol being its most active agonist endogenous ligand. ERα is also activated or inactivated by exogenous ligands. ER is overexpressed in hormone-dependent
Li Ming Gao, Wilson Maldonado, Xiomara Narváez-Pita, José A. Carmona-Negrón, Jesus Olivero-Verbel, Enrique Meléndez   +5 more
doaj   +1 more source

ADA3-containing complexes associate with estrogen receptor alpha [PDF]

Nucleic Acids Research, 2002
Transcriptional repression and activation by nuclear receptors (NRs) are brought about by coregulator complexes. These complexes modify the chromatin environment of target genes and affect the activity of the basal transcription machinery. We have previously implicated the yeast ADA3 protein in transcriptional activation by estrogen and retinoid X ...
Arndt, Benecke, Claudine, Gaudon, Jean-Marie, Garnier, Elmar, vom Baur, Pierre, Chambon, Régine, Losson   +5 more
openaire   +2 more sources

Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. [PDF]

PLoS ONE, 2013
An increasing body of evidence now links estrogenic signalling with the metabolic syndrome (MS). Despite the beneficial estrogenic effects in reversing some of the MS symptoms, the underlying mechanisms remain largely undiscovered.
Marko Matic, Galyna Bryzgalova, Hui Gao, Per Antonson, Patricia Humire, Yoko Omoto, Neil Portwood, Camilla Pramfalk, Suad Efendic, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

BMPR2 expression is suppressed by signaling through the estrogen receptor

Biology of Sex Differences, 2012
Background Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways.
Austin Eric D, Hamid Rizwan, Hemnes Anna R, Loyd James E, Blackwell Tom, Yu Chang, Phillips III John A, Gaddipati Radhika, Gladson Santhi, Gu Everett, West James, Lane Kirk B   +11 more
doaj   +1 more source

17β-Hydroxysteroid dehydrogenase type I and aromatase in ovarian cortical inclusion cysts

Endocrine Connections
Previous evidence suggests a link between the ovarian surface epithelium and cortical inclusion cysts and the origin of epithelial ovarian cancer.
Enrique Pedernera, Flavia Morales-Vásquez, Delia Pérez-Montiel, Elizabeth Rendon, Esteban Mena, Laura Diaz-Cueto, Carmen Mendez   +6 more
doaj   +1 more source

Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Clinics
Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Danylo Rafhael Costa-Silva, Carla Solange Escórcio-Dourado, Umbelina Soares Borges, Airton Mendes Conde-Junior, Maria da Conceição Barros-Oliveira, Emerson Brandão Sousa, Lorena da Rocha Barros, Luana Mota Martins, Gil Facina, Benedito Borges da-Silva   +11 more
doaj   +1 more source