The role of estrogen receptor beta in breast cancer [PDF]
Biomarker Research, 2020 Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve ...
Yujing Zhou, Xingdang Liu
doaj +6 more sources
Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor [PDF]
Frontiers in Oncology, 2020 Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the ...
Rahul Mal +25 more
doaj +2 more sources
Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer [PDF]
Chinese Medical Journal. Background:. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options.
Feng Xu +9 more
doaj +2 more sources
Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression [PDF]
Cell Death and Disease, 2022 Lung cancer is one of the most lethal malignant tumors in the world. The high recurrence and mortality rate make it urgent for scientists and clinicians to find new targets for better treatment of lung cancer.
Shiqing Liu +6 more
doaj +2 more sources
Coumestrol Alleviates Oxidative Stress, Apoptosis and Cognitive Impairments Through Hippocampal Estrogen Receptor-Beta in Male Mouse Model of Chronic Restraint Stress [PDF]
Pharmaceutical Sciences, 2022 Background: Coumestrol is well-known as a natural estrogen receptor-beta modulator. Since the role of estrogen receptors in controlling stressful situations has already been reported and their cognitive functions in hippocampus seem to be independent of ...
Kiarash Fekri +4 more
doaj +1 more source
Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]
Pharmaceutical Sciences Asia, 2022 Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai +3 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku +2 more
doaj +1 more source
SVU - International Journal of Medical Sciences, 2023 Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by
Omnia M.M. Badawy * +3 more
doaj +1 more source
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
Analysis of Four Polymorphisms Located at the Promoter of the Estrogen Receptor Alpha ESR1 Gene in a Population With Gender Incongruence [PDF]
, 2020 [Abstract] Introduction: Gender incongruence defines a state in which individuals feel discrepancy between the sex assigned at birth and their gender. Some of these people make a social transition from male to female (transwomen) or from female to male ...
Almaraz, Mari Cruz +8 more
core +1 more source