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Estrogen Signaling via Estrogen Receptor β [PDF]

Journal of Biological Chemistry, 2010
Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context.
Chunyan, Zhao, Karin, Dahlman-Wright, Jan-Åke, Gustafsson   +2 more
openaire   +2 more sources

Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2 [PDF]

Journal of Molecular Endocrinology, 2000
We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino acids inserted in the ligand binding domain of mERbeta1.
Lu, B., Leygue, E., Dotzlaw, H., Murphy, L. J., Murphy, L. C.   +4 more
openaire   +2 more sources

Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]

Seminars in Reproductive Medicine, 2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E., Cheng, You-Hong, Pavone, Mary Ellen, Xue, Qing, Attar, Erkut, Trukhacheva, Elena, Tokunaga, Hideki, Utsunomiya, Hiroki, Yin, Ping, Luo, Xia, Lin, Zhihong, Imir, Gonca, Thung, Stephen, Su, Emily J., Kim, J. Julie   +14 more
openaire   +4 more sources

Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells

BMC Cancer, 2017
Background Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.
Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck   +4 more
doaj   +1 more source

Expression of estrogen receptor beta correlates with adverse prognosis in resected pancreatic adenocarcinoma

BMC Cancer, 2018
Background The relevance of estrogen receptor (ER) expression in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. Clinical trials targeting ER with selective estrogen receptor modulators in pancreatic cancer did not show any benefit.
Hendrik Seeliger, Ioannis Pozios, Gerald Assmann, Yue Zhao, Mario H. Müller, Thomas Knösel, Martin E. Kreis, Christiane J. Bruns   +7 more
doaj   +1 more source

Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells

Tumor Biology, 2017
Human testis, gonocytes, and adult germ cells mainly express estrogen receptor beta, and estrogen receptor beta loss is associated with advanced tumor stage; however, the molecular mechanisms of estrogen receptor beta–protective effects are still to be ...
Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, Saveria Aquila   +10 more
doaj   +1 more source

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire   +2 more sources

Potent and Selective Estrogen Receptor-Beta Agonists Which Enhance Memory Consolidation in an Ovariectomized Mouse Model

Proceedings, 2019
Estrogen receptor-beta (ER-beta) is a drug target for memory consolidation in postmenopausal [...]
Alicia M. Hanson, Iresha Sampathi Perera, Jaekyoon Kim, Noreena Sweeney, Andrea Imhoff, Adam J. Wargolet, Rochelle M. Van Hart, Andrew Craig Mackinnon, Karyn M. Frick, Daniel S. Sem, William A. Donaldson   +10 more
doaj   +1 more source

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. [PDF]

PLoS ONE, 2009
While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones.
Aaron W James, Alexander A Theologis, Samantha A Brugmann, Yue Xu, Antoine L Carre, Philipp Leucht, Katherine Hamilton, Kenneth S Korach, Michael T Longaker   +8 more
doaj   +1 more source

Estrogen receptor beta in breast cancer

Molecular and Cellular Endocrinology, 2014
Estrogen is essential for growth and development of the mammary glands and has been associated with the promotion and growth of breast cancer and in line with this, most human breast cancers are initially estrogen-dependent and undergo regression when deprived of their supporting hormone.
Haldosén, Lars-Arne, Zhao, Chunyan, Dahlman-Wright, Karin   +2 more
openaire   +2 more sources