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Estrogen rescues heart failure through estrogen receptor Beta activation [PDF]

Biology of Sex Differences, 2018
Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga, Soban Umar, Gregoire Ruffenach, Laila Aryan, Jingyuan Li, Salil Sharma, Negar Motayagheni, Rangarajan D. Nadadur, Jean C. Bopassa, Mansoureh Eghbali   +9 more
doaj   +5 more sources

Estrogen receptor beta expression in prostate adenocarcinoma [PDF]

Diagnostic Pathology, 2011
Background Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many ...
Asgari Mojgan, Morakabati Arman
doaj   +3 more sources

The role of estrogen receptor beta in breast cancer [PDF]

Biomarker Research, 2020
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve ...
Yujing Zhou, Xingdang Liu
doaj   +2 more sources

Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor [PDF]

Frontiers in Oncology, 2020
Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the ...
Rahul Mal, Alexa Magner, Joel David, Jharna Datta, Meghna Vallabhaneni, Mahmoud Kassem, Mahmoud Kassem, Jasmine Manouchehri, Natalie Willingham, Daniel Stover, Daniel Stover, Jeffery Vandeusen, Jeffery Vandeusen, Sagar Sardesai, Sagar Sardesai, Nicole Williams, Nicole Williams, Robert Wesolowski, Robert Wesolowski, Maryam Lustberg, Maryam Lustberg, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Mathew A. Cherian, Mathew A. Cherian   +25 more
doaj   +2 more sources

Estrogen Receptor Beta Displays Cell Cycle-Dependent Expression and Regulates the G1 Phase through a Non-Genomic Mechanism in Prostate Carcinoma Cells

Cellular Oncology, 2008
Background: It is well known that estrogens regulate cell cycle progression, but the specific contributions and mechanisms of action of the estrogen receptor beta (ERβ) remain elusive.
Antoni Hurtado, Tomàs Pinós, Anna Barbosa-Desongles, Sandra López-Avilés, Jordi Barquinero, Jordi Petriz, Albert Santamaria-Martínez, Joan Morote, Inés de Torres, Joaquim Bellmunt, Jaume Reventós, Francina Munell   +11 more
doaj   +2 more sources

OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist [PDF]

Scientific Reports
Estrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young, Timothy H. Helms, Samuel K. Kulp, Adeoluwa A. Adeluola, Hanna S. Radomska, Tyler A. Wilson, Reena Shakya, Alyssa Kabat, Gillian Mulcahy, Abigail K. Mayo, Raphael A. Malbrue, William C. Kisseberth, Chad E. Bennett, Christopher C. Coss   +13 more
doaj   +2 more sources

Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer [PDF]

Chinese Medical Journal
. Background:. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options.
Feng Xu, Kun Xu, Lingling Fan, Xintong Li, Yiqiu Liu, Fang Yang, Chengjun Zhu, Xiaoxiang Guan, Ting Gao, Xiuyuan Hao   +9 more
doaj   +2 more sources

Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression [PDF]

Cell Death and Disease, 2022
Lung cancer is one of the most lethal malignant tumors in the world. The high recurrence and mortality rate make it urgent for scientists and clinicians to find new targets for better treatment of lung cancer.
Shiqing Liu, Chengping Hu, Min Li, Jian An, Wolong Zhou, Jia Guo, Yao Xiao   +6 more
doaj   +2 more sources

Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors. [PDF]

Sci Rep, 2022
Dalal H, Dahlgren M, Gladchuk S, Brueffer C, Gruvberger-Saal SK, Saal LH.   +5 more
europepmc   +3 more sources

Estrogen receptor beta activity contributes to both tumor necrosis factor alpha expression in the hypothalamic paraventricular nucleus and the resistance to hypertension following angiotensin II in female mice. [PDF]

Neurochem Int, 2022
Woods C, Contoreggi NH, Johnson MA, Milner TA, Wang G, Glass MJ.   +5 more
europepmc   +3 more sources