Results 131 to 140 of about 78,354 (303)

Evaluation of (Z)-endoxifen as a potential therapy for glioblastoma multiforme through computational and experimental analyses

Scientific Reports
(Z)-endoxifen (endoxifen) is the active metabolite of tamoxifen. Endoxifen is a potent antiestrogen that binds and blocks estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ).
Anastasia Shneyderman, Sandra S. Hammer, H. Lawrence Remmel, Alexander Veviorskiy, Khadija M. Alawi, Alina Ustiugova, Mikhail Korzinkin, Alex Zhavoronkov, Steven C. Quay   +8 more
doaj   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family

, 2010
Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core  

Estrogen signaling processes in fibroblasts: a scoping review

Frontiers in Endocrinology
Fibroblasts are a heterogeneous cell population with distinct functions, known to respond to estrogens through nuclear estrogen receptor alpha and beta (ERα, ERβ), and the membrane G protein-coupled estrogen receptor (GPER).
Neena Roy, Livio Casarini, Livio Casarini, Darya Smetanina, Shamsa Al Awar, Kornelia Zaręba   +5 more
doaj   +1 more source

Development of immunocompetent models for primary and metastatic ER+ breast cancer

Animal Models and Experimental Medicine, EarlyView.
This study explores syngeneic, immunocompetent models of ER+ breast cancer in 129S6/SvEv mice, using trackable tumor cells to model both primary tumors and metastasis. The models show promise, while also revealing limitations for studying advanced disease and immune interactions.
Devon M. Bull, Jody Hazlett, Emily Schulpen, Sophie Tunnicliffe, Alexander D. McLellan, Anita K. Dunbier   +5 more
wiley   +1 more source

Role of Estrogen Receptor-beta in Endometriosis

, 2012
Endometriosis is an estrogen-dependent disease. The biologically active estrogen, estradiol, aggravates the pathological processes (e. g., inflammation and growth) and the symptoms (e. g., pain) associated with endometriosis.
Dyson, Matthew, Attar, Erkut, Monsavais, Diana, Su, Emily J., Pavone, Mary Ellen, Bulun, Serdar E., Tokunaga, Hideki, Xue, Qing   +7 more
core   +1 more source

Histological Characterization and Comparative Transcriptomic Analysis of Gonads During Early Sex Differentiation in the Northern Snakehead (Channa argus)

Animal Research and One Health, EarlyView.
This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun, Donglei Sun, Haishen Wen, Xin Qi, Chao Li, Xiaoyan Zhang, Yun Li   +6 more
wiley   +1 more source

Estradiol-17 beta affects estrogen receptor distribution and elevates progesterone receptor content in baboon aorta.

, 1986
We used the synthetic estrogen R2858 (moxestrol) and estradiol-17 beta, respectively, to characterize the estrogen receptor in baboon (Papio sp.) aortic or myocardial cytoplasmic and nuclear preparations.
A L Lin, K D Carey, R Gonzalez, S A Shain   +3 more
core   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Andersson, AM, McLachlan, J, Steven F. Arnold, Arnold, SF, Philippe Grandjean, Andersen, HR, John P. Sumpter, Autrup, H, Henrik Leffers, Eva Bonefeld Jørgensen, Leffers, H, Ana M. Soto, Moller, A, Hummel, R, Oles-Karasko, A, Susan M. Thorpe, Beresford, NA, Perez, P, Thorpe, SM, Marianne Barfoed, Remy Le Guevel, Anette Møller, Nielsen, JB, Pakdel, F, Knud L. Pedersen, Pilar Perez, Christiansen, LB, Herman Autrup, Anita Oles-Karasko, Nicola A. Beresford, John McLachlan, Nicolas Olea, Skakkeboek, NE, Birgitte Gissel, Pedersen, KL, Korsgaard, B, Le Guevel, R, Grandjean, P, Lisette B. Christiansen, Bodil Korsgaard, Carlos Sonnenschein, Barfoed, M, Barfoed, N, Farzad Pakdel, René Hummel, Helle Raun Andersen, Gissel, B, Poul Bjerregaard, Bjerregaard, P, Soto, AM, Niels Erik Skakkebœk, Olea, N, Sumpter, JP, Anna-Maria Andersson, Jesper Bo Nielsen, Jorgensen, EB, Sonnenschein, C   +56 more
core   +1 more source