Estrogen receptor beta expression in prostate adenocarcinoma [PDF]
Diagnostic Pathology, 2011 Background Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many ...
Asgari Mojgan, Morakabati Arman
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Estrogen rescues heart failure through estrogen receptor Beta activation [PDF]
Biology of Sex Differences, 2018 Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga +9 more
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Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2 [PDF]
Journal of Molecular Endocrinology, 2000 We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino acids inserted in the ligand binding domain of mERbeta1.
Baisong Lu +4 more
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer [PDF]
Breast Cancer Research, 2000 Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone replacement, and for fertility regulation. Certain compounds that act through the estrogen receptor (ER), now referred to as selective estrogen ...
Benita S. Katzenellenbogen +1 more
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Estrogen receptor beta--a new dimension in estrogen mechanism of action [PDF]
Journal of Endocrinology, 1999 The cloning of estrogen receptor (ER ) has provided the first example of a steroid hormone receptor existing as two isoforms, each of which is encoded by a separate gene (Kuiper et al. 1996). The finding of ER was met with great surprise, as the existence of more than one estrogen receptor had been actively denied for several decades. Attempts to clone
JÅ Gustafsson
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Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA..
Biological and Pharmaceutical Bulletin, 2001 We investigated the estrogenic activities of isoflavone derivatives in competition binding assays with human estrogen receptor (hER) alpha or hER beta protein, and in a gene expression assay using a yeast system. Coumestrol binds as strongly as 17beta-estradiol to both hERs.
Keiko Morito +9 more
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Estrogen Receptor beta in Health and Disease1 [PDF]
Biology of Reproduction, 2005 Estrogens, acting through its two receptors, ESR1 (hereafter designated ER alpha) and ESR2 (hereafter designated ER beta), have diverse physiological effects in the reproductive system, bone, cardiovascular system, hematopoiesis, and central and peripheral nervous systems.
Jan-Åke Gustafsson +3 more
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Estrogen receptors alpha and beta in bone [PDF]
Bone, 2016 Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
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The Zebrafish (Danio rerio) Is a Relevant Model for Studying Sex-Specific Effects of 17β-Estradiol in the Adult Heart [PDF]
, 2019 Cardiovascular diseases are a major cause of morbidity and mortality, and there are significant sex differences therein. However, the underlying mechanisms are poorly understood.
Hassel, David +2 more
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Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells
BMC Cancer, 2017 Background Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.
Susanne Schüler-Toprak +4 more
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