Results 11 to 20 of about 71,407 (161)
Estrogen rescues heart failure through estrogen receptor Beta activation [PDF]
Biology of Sex Differences, 2018 Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga +9 more
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Estrogen receptor beta expression in prostate adenocarcinoma [PDF]
Diagnostic Pathology, 2011 Background Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many ...
Asgari Mojgan, Morakabati Arman
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The role of estrogen receptor beta in breast cancer [PDF]
Biomarker Research, 2020 Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve ...
Yujing Zhou, Xingdang Liu
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Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor [PDF]
Frontiers in Oncology, 2020 Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the ...
Rahul Mal +25 more
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OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist [PDF]
Scientific ReportsEstrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young +13 more
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Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer [PDF]
Chinese Medical Journal. Background:. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options.
Feng Xu +9 more
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Coumestrol Alleviates Oxidative Stress, Apoptosis and Cognitive Impairments Through Hippocampal Estrogen Receptor-Beta in Male Mouse Model of Chronic Restraint Stress [PDF]
Pharmaceutical Sciences, 2022 Background: Coumestrol is well-known as a natural estrogen receptor-beta modulator. Since the role of estrogen receptors in controlling stressful situations has already been reported and their cognitive functions in hippocampus seem to be independent of ...
Kiarash Fekri +4 more
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Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]
Pharmaceutical Sciences Asia, 2022 Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai +3 more
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Frontiers in Pharmacology, 2023 Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku +2 more
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SVU - International Journal of Medical Sciences, 2023 Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by
Omnia M.M. Badawy * +3 more
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