Synthesis and Evaluation of (1,4-Disubstituted)-1,2,3-triazoles as Estrogen Receptor Beta Agonists
Scientia Pharmaceutica, 2022 Estrogen receptors (ER) are nuclear hormone receptors which are responsible for sex hormone signaling in women. A series of (1,4-disubstituted)-1,2,3-triazoles 5–21 were prepared by reaction of azidophenols with terminal alkynes under Fokin reaction ...
Edward A. Wetzel +4 more
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Labor-associated gene expression in the human uterine fundus, lower segment, and cervix [PDF]
, 2006 Background Preterm labor, failure to progress, and postpartum hemorrhage are the common causes of maternal and neonatal mortality or morbidity. All result from defects in the complex mechanisms controlling labor, which coordinate changes in the ...
Aguan +37 more
core +3 more sources
Expression levels of sex hormone receptors in brains ofJapanese medaka, Oryzias latipes (Actinopterygii: Beloniformes: Adrianichthyidae) [PDF]
Acta Ichthyologica et Piscatoria, 2011 Background. In teleost fishes, the brain is the target organ for sex steroid hormones. The actions of sex steroid hormones are mediated by their receptors and play an important role in the regulation of endocrine function in the brain.
A. Ngamniyom, Y. Sasayama
doaj +3 more sources
Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia [PDF]
, 2018 Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment.
Bellini, Maria Jose +3 more
core +2 more sources
Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). [PDF]
, 2009 Matrix metalloproteinases (MMPs) have a crucial function in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic ...
Du, Sienmi +6 more
core +3 more sources
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β [PDF]
Endocrinology, 1998 The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand-binding domain and in the N-terminal transactivation domain. In this study, we investigated the estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ER alpha or ER beta ...
Paul T. van der Saag +7 more
openaire +3 more sources
Folia Histochemica et Cytobiologica, 2010 The biology of breast cancer is closely releted to sex steroid hormones. Estrogen receptor beta is overexpressed in around 70% breast cancer cases, referrd to as "ER positive".
Mariusz Kuźmicki +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Estrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1 ...
Felipe A. Bustamante-Barrientos +14 more
doaj +1 more source
Thyroid hormone receptors and ligand, tissue distribution and sexual behavior [PDF]
, 2018 The thyroid hormones (THs) triiodothyronine (T3) and tetraiodothyronine, or thyroxine (T4), not only dramatically impact on development and differentiation, but also on the sexual and reproductive function.
Carosa, E, Jannini, Ea, Lenzi, A
core +1 more source
Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]
, 2010 Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana +9 more
core +1 more source