Results 121 to 130 of about 304,831 (358)

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15 [PDF]

, 2013
Jacqueline Lehmann‐Che, Anne‐Sophie Hamy, Raphaël Porcher, Marc Barritault, Fatiha Bouhidel, Hanadi Habuellelah, Solenne Leman-Detours, Anne de Roquancourt, Laurence Cahen‐Doidy, E. Bourstyn, Patricia de Crémoux, C. de Bazelaire, M. Albiter, Sylvie Giacchetti, C. Cuvier, Anne Janin, Marc Espié, Philippe Bertheau, Philippe Bertheau   +18 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. [PDF]

, 2012
Summary In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using
Berger U, Berger U, Boecker W, Conde I, Eisman JA, Frampton RJ, Freake HC, Gombart AF, Jeschke U, Mason BH, Mylonas I, Remmele W, Ulmann A, Zinser GM   +13 more
core   +2 more sources

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Current Issues in Molecular Biology
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1).
Ju Rong, Xiaojun Xie, Yongdong Niu, Zhongjing Su   +3 more
doaj   +1 more source

The Sex Steroid Precursor DHEA Accelerates Cutaneous Wound Healing Via the Estrogen Receptors [PDF]

, 2005
Stuart J. Mills, Jason Ashworth, Stephen C. Gilliver, Matthew J. Hardman, Gillian S. Ashcroft   +4 more
openalex   +1 more source

Novel Advances in the Role of Selective Estrogen Receptor Modulators in Hormonal Replacement Therapy: A Paradigm Shift [PDF]

, 2023
Gunjan Motlani, Vidhi Motlani, Neema Acharya, Apoorva Dave, Soumya Pamnani, Drishti Somyani, Shruti Agrawal   +6 more
openalex   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety [PDF]

, 2015
Sang Jun Han, Khurshida Begum, Charles E. Foulds, Ross A. Hamilton, Suzanna Bailey, Anna Malovannaya, Doug W. Chan, Jun Qin, Bert W. O’Malley   +8 more
openalex   +1 more source

Plasma membrane estrogen receptors [PDF]

Trends in Endocrinology & Metabolism, 2009
It is now firmly established that estrogen and all sex steroid receptors exist in discrete cellular pools outside the nucleus. Estrogen receptors (ER) have been localized to the plasma membrane where both ERalpha and ERbeta function in a wide variety of cells and organs. ERs have also been found in discrete cytoplasmic organelles including mitochondria
openaire   +2 more sources