Results 111 to 120 of about 115,949,529 (167)

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

, 2019
The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear.
McConnell, Matthew J., Borowsky, Mark, Cheng, Tan-Yun, Siddiqi, Noman, Unnikrishnan, Meera, Fortune, Sarah M., Siegrist, M. Sloan, Rubin, Eric J., Moody, D. Branch   +8 more
core   +1 more source

Targeting type VII/ESX secretion systems for development of novel antimycobacterial drugs

, 2014
The emergence of multi- and extensively-drug resistant strains of Mycobacterium tuberculosis makes the development of novel anti-tubercular compounds and the identification of alternative mycobacterial drugable targets urgent priorities.
Brosch, Roland, Cascioferro, Alessandro, Manganelli, Riccardo, BOTTAI, DARIA, Serafini, Agnese   +4 more
core  

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinum. [PDF]

Proc Natl Acad Sci U S A, 2022
Cronin RM, Ferrell MJ, Cahir CW, Cahir CW, Champion MM, Champion PA.   +5 more
europepmc   +1 more source

High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis-Infected Macrophages to CD8 T Cells. [PDF]

J Immunol, 2023
Mott D, Yang J, Baer C, Papavinasasundaram K, Sassetti CM, Behar SM.   +5 more
europepmc   +1 more source

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. [PDF]

Proc Natl Acad Sci U S A, 2022
Osman MM, Shanahan JK, Chu F, Takaki KK, Pinckert ML, Pagán AJ, Brosch R, Conrad WH, Ramakrishnan L.   +8 more
europepmc   +1 more source

Genetically diverse CC and DO mouse models enable comprehensive assessments of novel tuberculosis vaccines

npj Vaccines
Development of a new vaccine for tuberculosis (TB) to replace the BCG vaccine has been hampered by the lack of a preclinical vaccine model that accurately reflects the genetic heterogeneity of the human population. We previously tested both Collaborative
Rocky Lai, Sherry L. Kurtz, Victoria Gould, Anthony Tran, Sam Afkhami, Roland Brosch, Cecilia S. Lindestam Arlehamn, Zhou Xing, Karen L. Elkins, Samuel M. Behar   +9 more
doaj   +1 more source

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.

, 2012
International audienceThe genome of Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems, ESX-1 to ESX-5, most of which are associated with genes encoding PE/PPE proteins, named after their N-terminal Pro-Glu (PE) or Pro-Pro-Glu (PPE)
Sayes, Fadel, Esin, Semih, Leclerc, Claude, Brosch, Roland, Simeone, Roxane, Degaiffier, Nathalie, Sun, Lin, Majlessi, Laleh, Di Luca, Mariagrazia, Bottai, Daria, Fiette, Laurence, Majlessi L., Brosch R, Sun L, Simeone R, Degaiffier N, Leclerc C, Sayes F, Fiette L   +18 more
core   +1 more source

Functional characterization of the virulence determinant ESX-1 from Mycobacterium tuberculosis

, 2018
Tuberculosis (TB) is a chronic infectious disease that mainly affects the lungs and causes extensive human morbidity and mortality. It results from infection with Mycobacterium tuberculosis, a slow-growing intracellular pathogen that can replicate and survive inside macrophages. M. tuberculosis relies on the specialised ESX-1 secretion system to export
openaire   +1 more source

Structure-Function Analyses of the Virulence-Associated Mycobacterial Secretion System ESX-1

Tuberculosis (TB), an airborne disease caused by Mycobacterium tuberculosis, remains the world’s leading cause of death from infectious disease. While there are effective drugs to prevent and treat TB disease, these regimens are many months long with ...
Rebecca Jane Prest (21574151)
core   +1 more source

Das ESX-1 Sekretionscluster von Streptococcus oralis Uo5

, 2011
Sekretionssysteme ermöglichen Bakterien nicht nur die Kommunikation mit ihrer Umwelt, sie spielen auch eine große Rolle in der Virulenz. Mit Virulenz werden auch Typ VII-Sekretionssysteme in Verbindung gebracht, die ausschließlich in Gram-positiven Bakterien vorkommen. Substrate dieser Systeme sind u.a.
openaire   +1 more source