Results 91 to 100 of about 115,949,529 (167)
Advanced Science, Volume 13, Issue 2, 9 January 2026.Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi +4 more
wiley +1 more source
Clinical &Translational Immunology, Volume 15, Issue 1, 2026.In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch +17 more
wiley +1 more source
Reduction of Charged Glycoconjugates in Tango2 KO Mouse Brain
Proteoglycan Research, Volume 4, Issue 1, January 2026.ABSTRACT The transport and Golgi organization 2 (TANGO2) gene has been identified to cause a rare recessive genetic disorder known as TANGO2‐deficiency disorder (TDD). TDD is a multi‐systemic disorder that can affect different organs including the brain, heart, and muscles, presenting as recurrent metabolic crises, muscle weakness, and neurological ...
Edward S. X. Moh +3 more
wiley +1 more source
, 2015 Pathogenesis of Mycobacterium tuberculosis depends on the secretion of key virulence factors, such as the 6 kDa early secreted antigenic target ESAT-6 (EsxA) and its protein partner, the 10 kDa culture filtrate protein CFP-10 (EsxB), via the ESX-1 ...
Brosch, Roland +4 more
core +1 more source
Expression and production of soluble Mycobacterium tuberculosis H37Rv mycosin-3
Biochemistry and Biophysics Reports, 2016 Mycobacteria encode five type VII secretion system (T7SS) or ESX for nutrient acquisition and virulence. Mycosins are membrane-anchored components of ESX with serine protease activity but an unidentified substrate range.
Zhuo Fang +2 more
doaj +1 more source
International Journal of Food Science, Volume 2026, Issue 1, 2026.Staphylococcus aureus is a leading cause of foodborne diarrhea, primarily due to staphylococcal enterotoxins (SEs). This study employed whole‐genome sequencing to characterize 106 S. aureus isolates from diarrheal patients in East China (2019–2024). We identified 23 sequence types, with ST398 (22.6%) and ST5 (7.5%) among the most prevalent.
Jinzhi Zhang +7 more
wiley +1 more source
Characterization of the ESX-1 (Snm) secretion system in mycobacteria
, 2009 Tuberculosis is a common and deadly disease caused by the Gram-positive bacteria Mycobacterium tuberculosis. Due to the unique nature of the extracytoplasmic localization of proteins in mycobacteria, specialized secretion systems are essential. Recent studies have identified a novel secretion pathway termed the ESX-1 (or Snm) secretion system.
openaire +1 more source
Pulmonary Medicine, Volume 2026, Issue 1, 2026.The rising incidence of nontuberculous mycobacteria (NTM) infections, particularly Mycobacterium kansasii (M. kansasii), and their overlapping clinical features with Mycobacterium tuberculosis (MTB) are leading to diagnostic ambiguity in tuberculosis‐endemic regions.
Meenakshi Chugh +4 more
wiley +1 more source
Rapid Molecular Diagnostics of Tuberculosis: What Do We Have, What Do We Need?
Pulmonary Medicine, Volume 2026, Issue 1, 2026.Smear microscopy and culture are conventional methods of tuberculosis (TB) diagnostics. Microscopy is fast and inexpensive but has low sensitivity, whereas culture is highly sensitive but may take several weeks. Molecular diagnostic (MDx) methods were widely introduced into TB diagnostics much later, in the early 2010s, when the GeneXpert system was ...
Bruno Luukinen, Divakar Sharma
wiley +1 more source