Results 81 to 90 of about 115,949,529 (167)
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Structural biology:Mycobacterial ESX secrets revealed [PDF]
, 2017 Structural analysis of the mycobacterial ESX-5 secretion complex presents an important step towards understanding how the ESX type VII (T7) secretion systems can translocate a multitude of substrates — including virulence factors involved in pathogenesis
Palmer T, Tracy Palmer, Palmer, Tracy
core +1 more source
Acidic pH Restricts Non‐Tuberculous Mycobacteria Replication
Molecular Microbiology, Volume 125, Issue 5, Page 375-388, May 2026.Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic environments within the macrophage enhances bacterial viability emphasising the role of acidic pH during NTM infections.
Parise K. Lockwood +3 more
wiley +1 more source
Tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum
Abstract Mycobacteria have a hydrophobic cell envelope that makes uniform growth in liquid culture challenging. Non-ionic detergents including Tween-80 and tyloxapol are commonly added to media when culturing mycobacterial species in the laboratory.
Owen A. Collars, Patricia A. Champion
openaire +3 more sources
Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner. [PDF]
PLoS Pathogens, 2017 Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence. Infected host cells generate double-membrane autophagosomes that mature in autolysosomes to engulf, kill and digest cytoplasmic pathogens.
Elena Cardenal-Muñoz +9 more
doaj +1 more source
Infect and Inject: How <i>Mycobacterium tuberculosis</i> Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. [PDF]
Microbiol Spectr, 2019 Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One important weapon within its fully loaded arsenal is the type VII secretion system. M. tuberculosis has five of them: ESAT-6 secretion systems (ESX) 1 to 5. ESX-1 has
Tiwari S +4 more
europepmc +2 more sources
Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales +11 more
wiley +1 more source
Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments
APMIS, Volume 134, Issue 3, March 2026.ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia +3 more
wiley +1 more source
Polar assembly and scaffolding proteins of the virulence‐associated ESX‐1 secretory apparatus in mycobacteria [PDF]
Molecular Microbiology, 2012 SummaryThe ESX‐1 secretion system is required for pathogenicity of Mycobacterium tuberculosis (Mtb). Despite considerable research, little is known about the structural components of ESX‐1, or how these proteins are assembled into the active secretion apparatus.
Samantha E, Wirth +6 more
openaire +2 more sources
EspI regulates the ESX-1 secretion system in response to ATP levels in Mycobacterium tuberculosis
, 2014 The function of EspI, a 70kDa protein in Mycobacterium tuberculosis, has remained unclear. Although EspI is encoded by a gene within the esx-1 locus, in this study we clarify previous conflicting results and show that EspI is not essential for ESX-1 ...
Chen, Jeffrey M. +11 more
core +1 more source