Results 61 to 70 of about 115,949,529 (167)

The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability. [PDF]

PLoS ONE, 2012
The recently described ESX-5 secretion system of Mycobacterium tuberculosis is one of the most important modulators of host-pathogen interactions due to its crucial impact on PPE protein secretion, cell wall stability and virulence.
Mariagrazia Di Luca, Daria Bottai, Giovanna Batoni, Mickael Orgeur, Anna Aulicino, Claudio Counoupas, Mario Campa, Roland Brosch, Semih Esin   +8 more
doaj   +1 more source

Microfluidic Profiling of an Immune Cell‐Associated Extracellular Vesicle Signature for Active Tuberculosis Diagnosis and Treatment Monitoring

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
Integrating microfluidic parallel detection with an innate immune extracellular vesicle signature enables rapid active tuberculosis diagnosis from 10 µL of plasma in 30 minutes, effectively discriminating non‐tuberculous respiratory diseases and monitoring treatment response.
Eun Ju Lee, Cheng Nie, Sunyoung Park, Yun‐Jeong Kang, Minji Kang, Jake Whang, Go‐Eun Choi, Hyejon Lee, San‐Nae Cho, Kyung‐A Hyun, Sunghyun Kim, Hyo‐Il Jung, Jungho Kim   +12 more
wiley   +1 more source

Real‐world use of Cenobamate in pediatric drug‐resistant epilepsy: A European multicenter retrospective study

Epilepsia Open, Volume 11, Issue 5, Page 1863-1870, October 2026.
Abstract Pediatric drug‐resistant epilepsy (DRE) remains a significant clinical challenge, with few effective pharmacological options. This European multicenter retrospective study assessed the real‐world efficacy, tolerability, and retention of off‐label cenobamate (CNB) in 108 children and adolescents with DRE (median age: 13.83 years, range 3.9–19.8)
Konstantin L. Makridis, Thomas Bast, Stéphane Auvin, Pavel Krsek, Matyas Ebel, Eva Breuer, Mira Beckhaus, Matúš Bašovský, Pavlína Danhofer, Ondřej Horák, Alessandro Orsini, Gonzalo Alonso Ramos Rivera, Hana Medřická, Steffen Syrbe, Angela M. Kaindl   +14 more
wiley   +1 more source

Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage.

PLoS ONE, 2020
Phthiocerol dimycocerosates (PDIMs) are a class of mycobacterial lipids that promote virulence in Mycobacterium tuberculosis and Mycobacterium marinum. It has recently been shown that PDIMs work in concert with the M.
Morwan M Osman, Antonio J Pagán, Jonathan K Shanahan, Lalita Ramakrishnan   +3 more
doaj   +1 more source

Phenotypic expression of the gene‐for‐gene interaction in plant pathogenic bacteria: An implication for resistance to bacterial diseases by plants

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Plant pathogenic bacteria cause massive losses in agriculture and damage to natural plant habitats. Bacterial pathogens not only reduce crop production, but they also reduce crop quality by releasing toxins into the environment. Pathogenic bacteria that invade plant tissues must overcome the plant's defense mechanisms. Plants possess an innate
Muluken Getahun, Zelalem Bekeko
wiley   +1 more source

Correlation of Phenotypic Profiles Using Targeted Proteomics Identifies Mycobacterial Esx‑1 Substrates

, 2015
The Esx/WXG-100 (ESAT-6/Wss) exporters are multiprotein complexes that promote protein translocation across the cytoplasmic membrane in a diverse range of pathogenic and nonpathogenic bacterial species.
Emily A. Williams (1342566), Patricia A. DiGiuseppe Champion (1342572), Matthew M. Champion (1342575), Richard S. Pinapati (1342569)   +3 more
core   +1 more source

ESX-1-induced apoptosis is involved in cell-to-cell spread of

Cellular Microbiology, 2013
Apoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of the infection. Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still remains unclear.
J. I. Aguilo, H. Alonso, S. Uranga, D. Marinova, A. Arbués, A. de Martino, A. Anel, M. Monzon, J. Badiola, J. Pardo, Roland Brosch, Carlos   +11 more
openaire   +4 more sources

Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death. [PDF]

PLoS Pathogens, 2012
Survival within macrophages is a central feature of Mycobacterium tuberculosis pathogenesis. Despite significant advances in identifying new immunological parameters associated with mycobacterial disease, some basic questions on the intracellular fate of
Roxane Simeone, Alexandre Bobard, Juliane Lippmann, Wilbert Bitter, Laleh Majlessi, Roland Brosch, Jost Enninga   +6 more
doaj   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source