ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria [PDF]
Cellular Microbiology, 2012 Mycobacterium species, including Mycobacterium tuberculosis and Mycobacterium leprae, are among the most potent human bacterial pathogens. The discovery of cytosolic mycobacteria challenged the paradigm that these pathogens exclusively localize within the phagosome of host cells.
Houben, D. +19 more
openaire +5 more sources
Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems. [PDF]
J Mol Biol, 2019 Type VII secretion systems (ESX) are responsible for transport of multiple proteins in mycobacteria. How different ESX systems achieve specific secretion of cognate substrates remains elusive.
Tuukkanen AT +14 more
europepmc +2 more sources
The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretion. [PDF]
J BacteriolABSTRACT Pathogenic mycobacteria are a significant global health burden. The ESX-1 secretion system is essential for mycobacterial pathogenesis. The secretion of ESX-1 substrates is required for phagosomal lysis, which allows the bacteria to enter the macrophage ...
Prest RJ, Korotkov KV, Champion PA.
europepmc +3 more sources
Molecular Motors of ESX-Type Secretion Systems [PDF]
, 2012 Tuberculosis is an enormous global health problem. Despite decades of research, the mechanism(s) by which Mycobacterium tuberculosis (Mtb) mediates virulence remains incompletely understood.
Ramsdell, Talia Lynn
core +6 more sources
Toxin secretion and trafficking by Mycobacterium tuberculosis
Nature Communications, 2021 The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al.
David Pajuelo +5 more
doaj +1 more source
Priming mycobacterial ESX-secreted protein B to form a channel-like structure
Current Research in Structural Biology, 2021 ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune system defence.
Abril Gijsbers +9 more
doaj +1 more source
Computational analysis of the ESX-1 region of Mycobacterium tuberculosis: insights into the mechanism of type VII secretion system. [PDF]
PLoS ONE, 2011 Type VII secretion system (T7SS) is a recent discovery in bacterial secretion systems. First identified in Mycobacterium tuberculosis, this secretion system has later been reported in organisms belonging to the Actinomycetales order and even to distant ...
Chandrani Das +2 more
doaj +1 more source
WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Mycobacteria use ESX systems to transport protein substrates across the cytoplasmic membrane. The ESX-1 system is required for mycobacterial pathogenesis in Mycobacterium tuberculosis (
Bosserman RE +8 more
europepmc +2 more sources
DisconnectingIn VitroESX-1 Secretion from Mycobacterial Virulence [PDF]
Journal of Bacteriology, 2013 Published ahead of print 11 October 2013 The views expressed in this Commentary do not necessarily reflect the views of the journal or of ASM.
openaire +2 more sources
EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis [PDF]
Journal of Bacteriology, 2012 ABSTRACT ESAT-6 system 1 (ESX-1)-mediated secretion in Mycobacterium tuberculosis is dependent on proteins encoded by the cotranscribed espA-espC-espD gene cluster. While the roles of EspA and EspC with respect to the ESX-1 secretion system have been actively investigated, the ...
Chen, Jeffrey M. +7 more
openaire +4 more sources