Polarly Localized EccE1 Is Required for ESX-1 Function and Stabilization of ESX-1 Membrane Proteins in Mycobacterium tuberculosis. [PDF]
J Bacteriol, 2020 ABSTRACT Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for ...
Soler-Arnedo P +4 more
europepmc +6 more sources
Modeling Tubercular ESX-1 Secretion Using Mycobacterium marinum. [PDF]
Microbiol Mol Biol Rev, 2020 Pathogenic mycobacteria cause chronic and acute diseases ranging from human tuberculosis (TB) to nontubercular infections.Mycobacterium tuberculosiscauses both acute and chronic human tuberculosis. Environmentally acquired nontubercular mycobacteria (NTM) cause chronic disease in humans and animals. Not surprisingly, NTM andM.
Chirakos AE +3 more
europepmc +4 more sources
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains. [PDF]
mBio, 2021 Data on the bacterial sex-mediated impact on mycobacterial evolution are limited. Hence, our results presented here are of importance as they clearly demonstrate the capacity of a wide range of human- and animal-adapted Mycobacterium tuberculosis complex (MTBC) strains to transfer chromosomal DNA to selected strains
Madacki J +5 more
europepmc +5 more sources
Loss of the ESX-5 secretion locus in <i>Mycobacterium tuberculosis</i> reshapes the mycomembrane and enhances ESX-1 substrate secretion. [PDF]
Proc Natl Acad Sci U S AThe ESX-5 secretion system, uniquely found in slow-growing mycobacteria, is predicted to secrete over 150 proteins across the inner membrane of Mycobacterium tuberculosis (M.tb).
Koleske B +9 more
europepmc +2 more sources
Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinum. [PDF]
J Bacteriol, 2022 Pathogenic mycobacteria are bacteria that pose a large burden to human health globally. The ESX-1 secretion system is required for pathogenic mycobacteria to survive within and interact with the host.
Sanchez KG +4 more
europepmc +3 more sources
The Role of ESX-1 in Mycobacterium tuberculosis Pathogenesis. [PDF]
Microbiol Spectr, 2017 ABSTRACT In this article, we have described several cellular pathological effects caused by the Mycobacterium tuberculosis ESX-1. The effects include induction of necrosis, NOD2 signaling, type I interferon production, and autophagy.
Wong KW.
europepmc +3 more sources
A Novel ESX-1 Locus Reveals that Surface-Associated ESX-1 Substrates Mediate Virulence in Mycobacterium marinum [PDF]
Journal of Bacteriology, 2014 ABSTRACT EsxA (ESAT-6) and EsxB (CFP-10) are virulence factors exported by the ESX-1 system in mycobacterial pathogens. In Mycobacterium marinum , an established model for ESX-1 secretion in Mycobacterium tuberculosis , genes required for ESX-1 export reside at the extended region ...
George M, Kennedy +4 more
openaire +2 more sources
A New ESX-1 Substrate in Mycobacterium marinum That Is Required for Hemolysis but Not Host Cell Lysis. [PDF]
Journal of Bacteriology, 2019 Matthew Champion +2 more
exaly +2 more sources
ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 The major Mycobacterium tuberculosis virulence factor ESAT-6 exported by the ESX-1 secretion system has been described as a pro-apoptotic factor by several independent groups in recent years, sustaining a role for apoptosis in M. tuberculosis pathogenesis.
Juan I Aguilo +8 more
openaire +4 more sources
iScience, 2022 Summary: The type VII secretion system (T7SS) of Mycobacterium tuberculosis secretes three substrate classes: Esx, Esp, and PE/PPE proteins, that play important roles in bacterial physiology and host interaction.
Yuchen Wang +10 more
doaj +1 more source