Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. [PDF]
PLoS ONE, 2019 The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection.
Abdallah M Abdallah +12 more
doaj +12 more sources
Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. [PDF]
PLoS Pathogens, 2010 The Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular events and host-pathogen interactions underlying Esx-1-mediated virulence in vivo remain unclear ...
Fredric Carlsson +7 more
doaj +5 more sources
Polar localization of virulence-related Esx-1 secretion in mycobacteria.
PLoS Pathogens, 2009 The Esx-1 (type VII) secretion system is critical for virulence of both Mycobacterium tuberculosis and Mycobacterium marinum, and is highly conserved between the two species.
Fredric Carlsson +3 more
doaj +5 more sources
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence With Cytosolic Immune Signaling and Improved TB Protection [PDF]
Cell Reports, 2017 Recent insights into the mechanisms by which Mycobacterium tuberculosis, the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design.
Wafa Frigui, Fadel Sayes, Wilbert Bitter
exaly +6 more sources
Modification of a PE/PPE Substrate Pair Reroutes an Esx Substrate Pair From the Mycobacterial ESX-1 Type VII Secretion System to the ESX-5 System [PDF]
Journal of Biological Chemistry, 2020 Bacterial type VII secretion systems (T7SSs) secrete a wide range of extracellular proteins that play important roles in bacterial viability and in interactions of pathogenic mycobacteria with their hosts.
Wilbert Bitter +2 more
exaly +4 more sources
Role of the Mycobacterium marinum ESX-1 Secretion System in Sliding Motility and Biofilm Formation [PDF]
Frontiers in Microbiology, 2018 Mycobacterium marinum is a close relative of Mycobacterium tuberculosis that can cause systemic tuberculosis-like infections in ectotherms and skin infections in humans.
Li-Yin Lai +5 more
doaj +5 more sources
The Fundamentals of Type VII secretion in Mycobacteria: An ESX-1 Perspective [PDF]
, 2023 A unique feature of mycobacteria, which includes the major human pathogen M. tuberculosis, is their impermeable cell envelope, containing two membranes. The mycobacterial outer membrane functionally resembles the outer membrane of Gram-negative bacteria but is differently composed of specific long-chain fatty acids, called mycolic acids, and other ...
Damen, Merel Petronella Maria; id_orcid
openaire +3 more sources
Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinum. [PDF]
Journal of Bacteriology, 2018 Mycobacterium marinum is a nontuberculous pathogen of poikilothermic fish and an opportunistic human pathogen. Like tuberculous mycobacteria, the M.
Rachel E Bosserman +2 more
exaly +3 more sources
A β-Lactamase based reporter system for ESX dependent protein translocation in mycobacteria. [PDF]
PLoS ONE, 2012 Protein secretion is essential for all bacteria in order to interact with their environment. Mycobacterium tuberculosis depends on protein secretion to subvert host immune response mechanisms. Both the general secretion system (Sec) and the twin-arginine
Tobias Rosenberger +2 more
doaj +2 more sources
Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
mBio, 2016 Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny.
Jeffrey M. Chen
doaj +2 more sources