Results 21 to 30 of about 115,949,529 (167)

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes [PDF]

mBio, 2016
Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5. One of the conserved T7S components is the serine protease mycosin (MycP). Strikingly, whereas MycP is essential for secretion, the protease activity of MycP1 in
Vincent J. C. van Winden, Roy Ummels, Sander R. Piersma, Connie R. Jiménez, Konstantin V. Korotkov, Wilbert Bitter, Edith N. G. Houben   +6 more
doaj   +2 more sources

A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. [PDF]

PLoS Pathogens, 2007
Specialized secretion systems of pathogenic bacteria commonly transport multiple effectors that act in concert to control and exploit the host cell as a replication-permissive niche.
Bryant McLaughlin, Janet S Chon, Jason A MacGurn, Fredric Carlsson, Terri L Cheng, Jeffery S Cox, Eric J Brown   +6 more
doaj   +6 more sources

Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity

Communications Biology
Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species ...
Wassim Daher, Vincent Le Moigne, Yara Tasrini, Shweta Parmar, Danielle L. Sexton, John Jairo Aguilera-Correa, Valentin Berdal, Elitza I. Tocheva, Jean-Louis Herrmann, Laurent Kremer   +9 more
doaj   +2 more sources

Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures [PDF]

mBio
Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing environments, despite its genome’s apparent stability.
Michael J. Luna, Peter O. Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S. Shell, Thomas R. Ioerger, Sarah M. Fortune, Maha R. Farhat, Christopher M. Sassetti   +10 more
doaj   +2 more sources

Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages [PDF]

mBio
Serine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored.
Esther Nobs, Katie Laschanzky, Kristina Munke, Elin Movert, Christine Valfridsson, Fredric Carlsson   +5 more
doaj   +2 more sources

The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in Mycobacterium marinum [PDF]

mSphere
The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors.
Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson, Rachel M. Cronin, Simon D. Weaver, Matthew M. Champion, Patricia A. Champion   +6 more
doaj   +2 more sources

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF. [PDF]

PLoS Pathogens, 2018
The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual ...
Trang H Phan, Lisanne M van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R Piersma, Connie R Jiménez, Astrid M van der Sar, Edith N G Houben, Wilbert Bitter   +10 more
doaj   +2 more sources

Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition [PDF]

mBio, 2014
The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation in the model organism ...
M. Sloan Siegrist, Magnus Steigedal, Rushdy Ahmad, Alka Mehra, Marte S. Dragset, Brian M. Schuster, Jennifer A. Philips, Steven A. Carr, Eric J. Rubin   +8 more
doaj   +2 more sources

Single nucleotide variation catalog from clinical isolates mapped on tertiary and quaternary structures of ESX-1-related proteins reveals critical regions as putative Mtb therapeutic targets [PDF]

Microbiology Spectrum
Proteins encoded by the ESX-1 genes of interest are essential for full virulence in all Mycobacterium tuberculosis complex (Mtbc) lineages, the pathogens causing the highest mortality worldwide.
Oren Tzfadia, Abril Gijsbers, Alexandra Vujkovic, Jihad Snobre, Roger Vargas, Klaas Dewaele, Conor J. Meehan, Maha Farhat, Sneha Hakke, Peter J. Peters, Bouke C. de Jong, Axel Siroy, Raimond B. G. Ravelli   +12 more
doaj   +2 more sources

Mycobacterium tuberculosis suppresses protective Th17 responses during infection [PDF]

eLife
Mycobacterium tuberculosis (Mtb) causes more deaths annually than any other pathogen, yet an effective vaccine remains elusive. IFN-γ-producing Th1 CD4+ T cells are necessary but insufficient for protection against infection.
Alex Zilinskas, Amir Balakhmet, Douglas Fox, Heyuan Michael Ni, Carolina Agudelo, Helia Samani, Sarah A Stanley   +6 more
doaj   +2 more sources