Results 51 to 60 of about 115,949,529 (167)

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis [PDF]

Journal of Structural Biology, 2015
Mycobacterium tuberculosis secretes multiple virulence factors during infection via the general Sec and Tat pathways, and via specialized ESX secretion systems, also referred to as type VII secretion systems. The ESX-1 secretion system is an important virulence determinant because deletion of ESX-1 leads to attenuation of M. tuberculosis.
Korotkova, Natalia, Piton, Jérémie, Wagner, Jonathan M., Boy-Röttger, Stefanie, Japaridze, Aleksandre, Evans, Timothy J., Cole, Stewart T., Pojer, Florence, Korotkov, Konstantin V.   +8 more
openaire   +4 more sources

ESX secretion system.

, 2015
(A) Organization of Ecc, Esx and Esp genes in the ESX complete ESX-1 –ESX-5 loci, M. bovis BCG Pasteur 1173P2 and the genome of MB1-MB4 mycobacteria isolates.
Javier Bezos (678585), Marinela Contreras (792370), Lucas Dominguez (3335391), Alejandro Cabezas-Cruz (420438), Raquel Tobes (64405), José de la Fuente (35632), Joaquín Vicente (66541), Iratxe Díez-Delgado (828691), Beatriz Romero (344380), Guillermo Madico (589429), Edward Jones-López (562729), Iker A. Sevilla (344375), Ramón Juste (432074), Christian Gortazar (2283736), Joseba M. Garrido (344374), Vladimir López (2583529), Marina Manrique (73136)   +16 more
core   +1 more source

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells [PDF]

Autophagy, 2012
Emerging evidence points to an important role of autophagy in the immune response mediated by dendritic cells (DC) against Mycobacterium tuberculosis (Mtb). Since current vaccination based on Bacillus Calmette-Guerin (BCG) is unable to stop the tuberculosis epidemic, a deeper comprehension of the alterations induced by Mtb in DC is essential for ...
Romagnoli, Alessandra, Etna, Marilena, Giacomini, Elena, Pardini, Manuela, Remoli, Maria Elena, Corazzari, Marco, Falasca, Laura, Goletti, Delia, Gafa, Valérie, Simeone, Roxane, Delogu, Giovanni, Piacentini, Mauro, Brosch, Roland, Fimia, Gian Maria, Coccia, Eliana   +14 more
openaire   +8 more sources

ESX-1 mutant strains have lost hemolytic activity.

, 2018
Contact-dependent hemolysis of red blood cells (RBCs) by various M. marinum strains grown in the presence of Tween-80. Hemolysis was quantified by determining the OD405 absorption of the released hemoglobin.
Roy Ummels (734424), Alba Rubio-Canalejas (5625056), Lisanne M. van Leeuwen (5625050), Trang H. Phan (5625047), Gunny van Stempvoort (2823650), Connie R. Jiménez (252347), Astrid M. van der Sar (422976), Sander R. Piersma (252344), Edith N. G. Houben (252320), Coen Kuijl (5625053), Wilbert Bitter (185600)   +10 more
core   +1 more source

Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

eLife, 2023
CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I
Owen Leddy, Forest M White, Bryan D Bryson   +2 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation

, 2011
During infection of humans and animals, pathogenic mycobacteria manipulate the host cell causing severe diseases such as tuberculosis and leprosy. To understand the basis of mycobacterial pathogenicity, it is crucial to identify the molecular virulence ...
Maaike van Zon, Bitter, W.; id_orcid, Punder, K. de, Wel, N.N. van der, de Punder, K., De Punder, Karin, Korbee, Cees J., Astrid M. van der Sar, Korbee, C.J., Peters, P.J., Bitter, Wilbert M., Van Zon, Maaike, Wilson, L., Nicole N. van der Wel, Abdallah, Abdallah, Peter J. Peters, Peters, Peter J., Abdallah, A.M., Savage, Nigel D L, Tom H. M. Ottenhoff, Bestebroer, Jovanka, van der Sar, A.M., Ottenhoff, T.H.M., Ottenhoff, Tom Hm M, Wilbert Bitter, Nigel D. L. Savage, Bestebroer, J., Abdallah M. Abdallah, Zon, M. van, Bitter, W., Cees J. Korbee, Jovanka Bestebroer, Karin de Punder, van der Wel, N.N., Savage, N.D.L., Sar, A.M. van der, van Zon, M., van der Sar, Astrid M., Louis Wilson, Van Der Wel, Nicole N., Wilson, Louis D.   +40 more
core   +1 more source

pH-responsive substrate switching in mycobacterial type VII ESX secretion

mSphere
During infection, pathogenic mycobacteria reside within phagosomes of varying acidity based on the macrophage activation state. The ESX-1 secretion system (early secreted antigen 6 kilodaltons [ESAT-6] system 1) delivers protein virulence factors ...
Owen A. Collars, Richard L. Hernandez, Simon D. Weaver, Rebecca J. Prest, Caleb Manu, Gopinath Viswanathan, Rachel M. Cronin, Bradley S. Jones, David M. Tobin, Matthew M. Champion, Patricia A. Champion   +10 more
doaj   +1 more source

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2821-2855, November 2026.
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Michael Dare Asemoloye
wiley   +1 more source

EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis.

PLoS Pathogens, 2018
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of
Claudia Sala, Nina T Odermatt, Paloma Soler-Arnedo, Muhammet F Gülen, Sofia von Schultz, Andrej Benjak, Stewart T Cole   +6 more
doaj   +1 more source