Results 71 to 80 of about 115,949,529 (167)

Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein. [PDF]

PLoS Pathogens, 2012
The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR.
Benjamin Blasco, Jeffrey M Chen, Ruben Hartkoorn, Claudia Sala, Swapna Uplekar, Jacques Rougemont, Florence Pojer, Stewart T Cole   +7 more
doaj   +1 more source

IMB-BZ as an Inhibitor Targeting ESX-1 Secretion System to Control Mycobacterial Infection

The Journal of Infectious Diseases, 2021
Abstract Background Resistance to anti-tuberculosis (TB) drugs is a major issue in TB control, and demands the discovery of new drugs targeting the virulence factor ESX-1. Methods We first established a high ...
Pingping, Jia, Yi, Zhang, Jian, Xu, Mei, Zhu, Shize, Peng, Yongxin, Zhang, Jianyuan, Zhao, Xiaoyu, Li, Kaixia, Mi, Dan, Yan, Yucheng, Wang, Liyan, Yu, Yu, Lu, Hanping, Shi, Shan, Cen   +14 more
openaire   +2 more sources

Ebselen inhibits mycobacterial ESX-1 secretion through modification of EccA1 [PDF]

, 2019
Abstract The type VII secretion system ESX-1 (ESAT-6 secretion system 1) is required for virulence in Mycobacterium tuberculosis and M. marinum . Here, we identify the clinical drug candidate ebselen as an inhibitor of ESX-1 secretion in both organisms. We find that ebselen inhibits the activity of the ESX-1 AAA+ ATPase EccA1, which is required for
Osman, Morwan M., Pinckert, Malte L., Peak-Chew, Sew, Troll, Mark A., Conrad, William H., Ramakrishnan, Lalita   +5 more
openaire   +2 more sources

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection. [PDF]

PLoS Pathogens, 2016
Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25-pe19)
Fadel Sayes, Alexandre Pawlik, Wafa Frigui, Matthias I Gröschel, Samuel Crommelynck, Catherine Fayolle, Felipe Cia, Gregory J Bancroft, Daria Bottai, Claude Leclerc, Roland Brosch, Laleh Majlessi   +11 more
doaj   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, Volume 2, Issue 2, Page 1-20, June 2026.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis [PDF]

Journal of Biological Chemistry, 2008
Rv3868, a conserved hypothetical protein of the ESAT-6 secretion system of Mycobacterium tuberculosis, is essential for the secretion of at least four virulence factors. Each protein chain is approximately 63 kDa and assembles into a hexamer. Limited proteolysis demonstrates that it consists of two domains joined by a linker. The N-terminal domain is a
Amit, Luthra, Anjum, Mahmood, Ashish, Arora, Ravishankar, Ramachandran   +3 more
openaire   +2 more sources

The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness.

PLoS Pathogens, 2022
ESX type VII secretion systems are complex secretion machineries spanning across the mycobacterial membrane and play an important role in pathogenicity, nutrient uptake and conjugation. We previously reported the role of ESX-4 in modulating Mycobacterium
Marion Lagune, Vincent Le Moigne, Matt D Johansen, Flor Vásquez Sotomayor, Wassim Daher, Cécile Petit, Gina Cosentino, Laura Paulowski, Thomas Gutsmann, Matthias Wilmanns, Florian P Maurer, Jean-Louis Herrmann, Fabienne Girard-Misguich, Laurent Kremer   +13 more
doaj   +1 more source

Cell Envelope Remodeling and Lipid Metabolism Coordinate Extracellular Vesicle Output in Mycobacterium Tuberculosis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global cause of death due to the pathogen's highly adaptive physiology and its ability to manipulate host immunity. Despite extensive study, our understanding of Mtb biology during infection remains incomplete, limiting the development of new diagnostics ...
José L. Serrano‐Mestre, Laura Lerma, Lucía Vázquez‐Iniesta, Vivian C. Salgueiro‐Toledo, Ainhoa Palacios, Sogol Alebouyeh, Andrea Doddi, Felix Elortza, Mikel Azkargorta, Leticia Sampedro, Estibaliz Atondo, Miguel Ángel Pacual‐Itoiz, Oren Mayer, Torin Westwood, William R. Jacobs Jr, Rafael Prados‐Rosales   +15 more
wiley   +1 more source

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10.

PLoS Pathogens, 2016
Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in slow-growing mycobacteria, the type VII secretion system ESX-5 plays a major role in the integrity and ...
Louis S Ates, Aniek D van der Woude, Jovanka Bestebroer, Gunny van Stempvoort, René J P Musters, Juan J Garcia-Vallejo, Daisy I Picavet, Robert van de Weerd, Massimiliano Maletta, Coenraad P Kuijl, Nicole N van der Wel, Wilbert Bitter   +11 more
doaj   +1 more source

Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in the outer membrane transport of proteins

mSphere, 2023
Mycobacteria utilize type VII secretion systems (T7SSs) to secrete proteins across their highly hydrophobic and diderm cell envelope. Pathogenic mycobacteria have up to five different T7SSs, called ESX-1 to ESX-5, which are crucial for growth and ...
C. M. Bunduc, Y. Ding, C. Kuijl, T. C. Marlovits, W. Bitter, E. N. G. Houben   +5 more
doaj   +1 more source