Results 101 to 110 of about 115,949,529 (167)

ESX Secretion-Associated Protein C From Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2019
Mycobacterium tuberculosis, as a facultative intracellular pathogen, can interact with host macrophages and modulate macrophage function to influence innate and adaptive immunity.
Qinglong Guo, Jing Bi, Jing Bi, Ming Li, Wenxue Ge, Ying Xu, Weixing Fan, Honghai Wang, Xuelian Zhang   +8 more
doaj   +1 more source

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria.

, 2018
The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection.
Borggreve, S, Pain, Arnab, Adroub, Sabir, Zhang, Huoming, Abdallah, Abdallah, Guan, Qingtian, Ummels, Roy, Malas, Tareq Majed Yasin, Naeem, Raeece, Otto, Thomas, Bitter, Wilbert, Weerdenburg, Eveline   +11 more
core   +1 more source

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG 1on virulence of Mycobacterium tuberculosis [PDF]

, 2011
Background. The pathogenesis of Mycobacterium tuberculosis largely depends on the secretion of the 6-kD early secreted antigenic target ESAT-6 (EsxA) and the 10-kD culture filtrate protein CFP-10 (EsxB) via the ESX-1/typeVII secretion system.
Brosch, Roland, Cole, Stewart T., Lenormand, Pascal, Laleh Majlessi, Roxane Simeone, Leclerc, Claude, Chen, Jeffrey, Jeffrey Chen, BOTTAI, DARIA, Frigui, Wafa, Ida Rosenkrands, Roland Brosch, Laurent, Christine, Daria Bottai, Stewart T. Cole, Claude Leclerc, Simeone, Roxane, Wafa Frigui, Huerre, Michel, Michel Huerre, Rosenkrands, Ida, Pascal Lenormand, Majlessi, Laleh, Christine Laurent, Cole, Stewart   +24 more
core   +2 more sources

Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex

Nature Communications
Mycobacterium tuberculosis uses five ESX systems to secrete effector proteins with distinct functions essential for the pathogen’s growth and virulence. The current paradigm assumes that each ESX system secretes a distinct set of effector proteins. Here,
Rashmi Ravindran Nair, Virginia Meikle, Swati Dubey, Mikhail Pavlenok, Anna D. Tischler, Michael Niederweis   +5 more
doaj   +1 more source

Functional analysis of type VII secretion system links to host immune evasion mechanism in Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology
Mycobacterium tuberculosis causes tuberculosis, an infectious disease; this acid-fast bacillus has various functions that enable it to survive within the host. Importantly, the type VII secretion system plays a vital role in host immune evasion. However,
Karthikeyan Sundaram, Sridhar Rathinam, Ramalingam Bethunaickan, Uma Devi Ranganathan, Venkataraman Prabhu, Madhavan Dhanapal   +5 more
doaj   +1 more source

Combined effect of esaxerenone and dapagliflozin on aldosterone-mediated sodium reabsorption and potassium excretion

Frontiers in Physiology
IntroductionThe efficacy of nonsteroidal mineralocorticoid receptor blockers (MRBs) in inhibiting the progression of diabetic kidney disease (DKD) is well-known. However, MRB therapy often leads to hyperkalemia and remains a major concern. Recent studies
Motonobu Nakamura, Nobuhiko Satoh, Tomohito Mizuno, Mayuko Takagi, Shoko Horita, Shoko Horita, Masaomi Nangaku   +6 more
doaj   +1 more source

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component

Disease Models & Mechanisms, 2011
SUMMARY The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils and lymphocytes.
Esther J. M. Stoop, Tim Schipper, Sietske K. Rosendahl Huber, Alexander E. Nezhinsky, Fons J. Verbeek, Sudagar S. Gurcha, Gurdyal S. Besra, Christina M. J. E. Vandenbroucke-Grauls, Wilbert Bitter, Astrid M. van der Sar   +9 more
doaj   +1 more source

Structural and functional characterization of the mycobacterial ESX-1 secretion system

, 2016
Human tuberculosis (TB) is a frequently fatal lung disease mostly caused by Mycobacterium tuberculosis (M. tb), a slow-growing intracellular pathogen. M. tb utilizes the ESX-1 secretion system, classified as type VII, to export the virulence factors needed for host infection and pathogenesis.
openaire   +1 more source

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

, 2009
The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear.
Siegrist, M. S., McConnell, Matthew J., Borowsky, Mark, Fortune, S. M., Unnikrishnan, Meera, Cheng, T.-Y., Siddiqi, N., Rubin, Eric J., Moody, D. Branch   +8 more
core   +1 more source

Upregulation of ESX loci and esat-6-like genes.

, 2014
(A) Genes upregulated within ESX-1 locus. (B) Genes upregulated within ESX-5 locus. (C) Total genes encoding ESAT-6-like proteins upregulated in the M. tb genome.
Susan Zolla-Pazner (156004), Hualin Li (438300), Suman Laal (85057), Lu Meng (289653), Zhengyu Peng (585270), Krishna K. Singh (585269), Michelle B. Ryndak (585268)   +6 more
core   +1 more source