Results 11 to 20 of about 1,697 (183)

Bacteriophage-mediated restoration of epithelial integrity, DNA damage response, and transcriptomic homeostasis in colon organoids exposed to ETBF and pks + E. coli [PDF]

Scientific Reports
Colorectal cancer (CRC)–associated pathobionts such as Enterotoxigenic Bacteroides fragilis (ETBF) and colibactin-producing (pks+) Escherichia coli disrupt epithelial barrier function, promote chronic inflammation, and induce genotoxic stress.
Myoung Hyoun Song, Eun Kyoung Oh, In Hwang Kim, Jee-Soo Son, Seong Jun Yoon, Jin-Young Kim, Min Jung Kim, Seung-Yong Jeong, Ji Won Park, Ja-Lok Ku   +9 more
doaj   +5 more sources

Physicochemical Properties of Pre-Treatment Tartary Buckwheat Flour and Its Effect on Dough and Noodle Quality [PDF]

Foods
This study compared physical and chemical properties of extruded Tartary buckwheat flour (ETBF) and microwave-extruded Tartary buckwheat flour (M-ETBF), as well as the quality of dough and noodles made with these flours.
Shengnan Xu, Xueqin Li, Jiayin Lv, Jie Chen, Kunlun Liu   +4 more
doaj   +2 more sources

Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic Bacteroides fragilis-Induced Colitis and Tumorigenesis

Toxins
The human colonic commensal enterotoxigenic Bacteroides fragilis (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces colitis via the Bacteroides fragilis toxin (BFT).
Soonjae Hwang, Minjeong Jo, Ju-Eun Hong, Woo-Seung Kim, Da-Hye Kang, Sang-Hyeon Yoo, Kyungsu Kang, Ki-Jong Rhee   +7 more
doaj   +2 more sources

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response [PDF]

MedComm (2020)
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Xu M, Yu J, Chen Y, Ge S, Ye L, Wang Y, Zhou Y, Jia R.   +7 more
europepmc   +2 more sources

Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia.

PLoS ONE, 2017
BackgroundEnterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes.
Rachel V Purcell, John Pearson, Alan Aitchison, Liane Dixon, Frank A Frizelle, Jacqueline I Keenan   +5 more
doaj   +2 more sources

KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis

Gut Microbes
KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between the gut microbiota and CRC has been extensively documented, it is unclear whether KRAS mutations can regulate the gut microbiota.
Yizhen Chen, Shaolin Liu, Song Tan, Yuanyuan Zheng, Yifan Chen, Changshun Yang, Shengtao Lin, Yulong Mi, Weihua Li   +8 more
doaj   +2 more sources

Outer membrane vesicles secreted by Bacteroides fragilis inhibit CFTR chloride secretion by human colon organoids [PDF]

Infection and Immunity
The goals of this study were to develop a model to study host-pathogen interactions in primary human colon organoids and to test the hypothesis that Bacteroides fragilis toxin (BFT-2) secreted in outer membrane vesicles (OMVs) modulates mucosal immunity ...
Roxanna Barnaby, Amanda Nymon, Paige Salerno, Carolyn T. Roche, Young Ah Goo, Byoung-Kyu Cho, Timothy B. Gardner, Zdenek Svindrych, Douglas J. Taatjes, Thomas H. Hampton, Benjamin Ross, Bruce A. Stanton   +11 more
doaj   +2 more sources

Biological Mechanisms of Enterotoxigenic Bacteroides fragilis Toxin: Linking Inflammation, Colorectal Cancer, and Clinical Implications

Toxins
Enterotoxigenic Bacteroides fragilis (ETBF) has emerged as a gut microbiome pathogen that can promote intestinal inflammation and contribute to colorectal cancer (CRC).
Seyedesomaye Jasemi, Paola Molicotti, Milena Fais, Ilaria Cossu, Elena Rita Simula, Leonardo A. Sechi   +5 more
doaj   +3 more sources

Bacteroides fragilis Toxin Induces Sequential Proteolysis of E-Cadherin and Inflammatory Response in Mouse Intestinal Epithelial Cell Line

Microorganisms
Enterotoxigenic Bacteroides fragilis (ETBF) is an intestinal bacterium that secretes the metalloprotease Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage and interleukin-8 secretion in human intestinal epithelial cell lines.
Woo-Seung Kim, Soonjae Hwang, Sun-Yeong Gwon, Minjeong Jo, Sang-Hyeon Yoo, Jiyun Hong, Ha-Neul Jang, Ju-Eun Hong, Da-Hye Kang, Miyong Yun, Ki-Jong Rhee   +10 more
doaj   +2 more sources

Intratumoral Bacterial Profiles, Bacterial Co-Detection Patterns, and Molecular Alterations in Colorectal Cancer and Colorectal Polyps: A Vietnamese Cohort Study [PDF]

Microorganisms
Intratumoral microbiota may contribute to colorectal cancer (CRC), but their relationships with bacterial co-occurrence, relative bacterial loads, and molecular alterations remain incompletely understood.
Vu Son Giang, Ho Van Son, Dao Tien Manh, Nguyen Thanh Tung, Nguyen Phuong Thao, Nguyen Thi Than, Nguyen Dang Tung, Tran Viet Hao, Le Duy Cuong   +8 more
doaj   +2 more sources