Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella. [PDF]
Ann N Y Acad SciThis work establishes a newly developed Galleria mellonella infection model as a powerful, ethical platform for studying Bacteroides fragilis pathogenesis and therapy. Leveraging this model, the study identifies MOA4 as a potent BFT‐3 inhibitor that improves host survival, increases bacterial clearance, and synergizes with antibiotics without toxicity.
Jiménez-Alesanco A +6 more
europepmc +2 more sources
Contribution of genetic and environmental factors to obesity indices and their overlap. [PDF]
Diabetes Obes MetabAbstract Aims Numerous indices have been developed to quantify obesity and the distribution of body fat; however, none are sufficient alone, and combined usage is complicated by their potential intercorrelation. This study aims to quantify genetic and environmental influences on anthropometric measures, 12 derived obesity indices and the extent of ...
Ani A, Nolte IM, Vaez A, Snieder H.
europepmc +2 more sources
Prevalence of enterotoxigenic Bacteroides fragilis in patients with colorectal cancer: a systematic review and meta-analysis [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe gut microbiome, specifically enterotoxigenic Bacteroides fragilis (ETBF), has been reported to play a role in colorectal cancer development.
Shijun Xia +4 more
doaj +2 more sources
Purification and Characterization of His-Tagged Recombinant Bacteroides fragilis Toxin-2 Variants In Vitro and In Vivo [PDF]
ToxinsBacteroides fragilis is a major commensal bacterium of the human colon. However, enterotoxigenic B. fragilis (ETBF) secretes B. fragilis toxin (BFT), a zinc-dependent metalloprotease that cleaves E-cadherin and promotes chronic inflammation and ...
Woo-Seung Kim +4 more
doaj +2 more sources
Association of Enterotoxigenic <i>Bacteroides fragilis</i> with Immune Modulation in Colorectal Cancer Liver Metastasis. [PDF]
Cancers (Basel)Background: Enterotoxigenic Bacteroides fragilis (ETBF) carries the bft toxin gene, which influences the host immune response and inflammatory pathways and promotes colorectal cancer (CRC).
Saito R +11 more
europepmc +2 more sources
The “Direct Structural Disruption” Hypothesis: Bacteroides fragilis Toxin as a Potentiating Cofactor in MASH Pathogenesis [PDF]
ToxinsMetabolic dysfunction-associated steatohepatitis (MASH) is a complex, multifactorial disease heavily influenced by the gut–liver axis. While enterotoxigenic Bacteroides fragilis (ETBF) and its principal virulence factor, B.
Ju-Eun Hong, Soonjae Hwang
doaj +2 more sources
Outer Membrane Vesicles From Bacteroides fragilis Contain Coding and Non‐Coding Small RNA Species That Modulate Inflammatory Signalling in Intestinal Epithelial Cells [PDF]
Journal of Extracellular BiologyAlterations to the community structure and function of the microbiome are associated with changes to host physiology, including immune responses. However, the contribution of microbe‐derived RNAs carried by outer membrane vesicles (OMVs) to host immune ...
Aadil Sheikh +20 more
doaj +2 more sources
Bacteroides fragilis toxin (BFT) detection and neutralization using phage display-derived synthetic hagfish VLRBs. [PDF]
PLoS ONEEnterotoxigenic Bacteroides fragilis (ETBF) weakens the intestinal epithelial barrier and promotes inflammatory signaling through secretion of B. fragilis toxin (BFT), a metalloprotease associated with chronic intestinal inflammation.
Abigail Joy D Rodelas-Angelia +10 more
doaj +2 more sources
The Ambivalent Nature of Bacteroides fragilis and the Interaction with Clostridioides difficile: Benefits and Disadvantages for the Human Host [PDF]
ToxinsBacteroides fragilis is a usually beneficial colonizer of the human gut that can also act as an opportunistic pathogen, causing infection and contributing to the development and progression of important diseases.
Patrizia Spigaglia
doaj +2 more sources
Frontiers in Oncology, 2021 ObjectiveUp to now, non-invasive diagnosis of laterally spreading tumor (LST) and prediction of adenoma recurrence after endoscopic resection of LSTs is inevitable.
Xiaonan Shen +9 more
doaj +1 more source