Results 31 to 40 of about 1,697 (183)

Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort

Gut Microbes, 2021
Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse.
Julia Butt, Mazda Jenab, Jill Werner, Veronika Fedirko, Elisabete Weiderpass, Christina C. Dahm, Anne Tjønneland, Anja Olsen, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias Schulze, Domenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Carla H. Van Gils, Inger Torhild Gram, Marko Lukic, Núria Sala, María José Sánchez Pérez, Eva Ardanaz, María-Dolores Chirlaque, Richard Palmquist, Thyra Löwenmark, Ruth C Travis, Alicia Heath, Amanda J Cross, Heinz Freisling, Semi Zouiouich, Elom Aglago, Tim Waterboer, David J. Hughes   +37 more
doaj   +1 more source

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

iScience, 2023
Summary: The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S ...
Naomi G. Wilson, Ariel Hernandez-Leyva, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau   +11 more
doaj   +1 more source

Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin

Frontiers in Immunology, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) can rapidly secrete an enterotoxin termed B. fragilis toxin (BFT), which is thought to be the only recognized virulence factor in ETBF.
Yucheng Guo, Zhenlin Ouyang, Wenbo He, Jiaxin Zhang, Qian Qin, Min Jiao, Serge Muyldermans, Fang Zheng, Yurong Wen   +8 more
doaj   +1 more source

High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients

BMC Cancer, 2021
Background The association between specific bacteria and colorectal cancer (CRC) has been proposed. Only a few studies have, however, investigated this relationship directly in colorectal tissue with conflicting results.
Nasibeh Khodaverdi, Habib Zeighami, Ahmad Jalilvand, Fakhri Haghi, Negar Hesami   +4 more
doaj   +1 more source

ENTEROTOXIGENIC BACTEROIDES FRAGILIS (ETBF) INDUCES GENETIC AND EPIGENETIC CHANGES IN COLON EPITHELIAL CELLS WHICH CONTRIBUTE TO TUMORIGENESIS [PDF]

, 2022
Rates of colorectal cancer (CRC) are increasing in younger individuals, and CRC remains the second most frequent cause of cancer-related deaths globally.
Allen, Jawara
core  

Association of F. nucleatum and ETBF positivity with clinical lesions in the colonic biopsy cohort, adjusted for age and gender.

, 2022
Association of F. nucleatum and ETBF positivity with clinical lesions in the colonic biopsy cohort, adjusted for age and gender.
John F. Pearson (9338604), Rachel V. Purcell (3713716), Jacqueline I. Keenan (3713713), Frank A. Frizelle (3212937), Alan Aitchison (667406)   +4 more
core   +1 more source

Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis

Frontiers in Immunology, 2023
IntroductionObesity, an independent risk factor for breast cancer growth and metastatic progression, is also closely intertwined with gut dysbiosis; and both obese state and dysbiosis promote each other.
Sheetal Parida, Sumit Siddharth, Himavanth R. Gatla, Shaoguang Wu, Guannan Wang, Guannan Wang, Kathleen Gabrielson, Kathleen Gabrielson, Cynthia L. Sears, Cynthia L. Sears, Cynthia L. Sears, Brian H. Ladle, Brian H. Ladle, Dipali Sharma   +13 more
doaj   +1 more source

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice [PDF]

, 2009
Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage ...
Rabizadeh, S., Karim, B., Sartor, R. B., Golenbock, D., Sears, C. L., Shin, J., Gan, C. M., Housseau, F., Wu, X., Franco, A. A., Rhee, K.-J., Wu, S., Golub, J. E., Hamad, A. R., Mathews, L. E., Huso, D. L.   +15 more
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Promotion of Colitis in B Cell-Deficient C57BL/6 Mice Infected with Enterotoxigenic Bacteroides fragilis

, 2023
Enterotoxigenic Bacteroides fragilis (ETBF) causes colitis and is implicated in inflammatory bowel diseases and colorectal cancer. The ETBF-secreted B. fragilis toxin (BFT) causes cleavage of the adherence junction, the E-cadherin, resulting in the large
Minjeong Jo, Woo-Seung Kim, Da-Hye Kang, Jung-Yoon Yoo, Ju-Eun Hong, Sang-Hyeon Yoo, Chang-Gun Lee, Soonjae Hwang, Ki-Jong Rhee   +8 more
core   +1 more source

Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis

Gut Pathogens, 2017
Purpose Ulcerative colitis (UC) as a type of inflammatory bowel disease (IBD), presumed to occur as a consequence of increased immune responses to intestinal microbiota in genetically susceptible individuals.
Samin Zamani, Sonia Hesam Shariati, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Akram Sarabi Asiabar, Saied Bokaie, Bizhan Nomanpour, Leonardo Antonio Sechi, Mohammad Mehdi Feizabadi   +8 more
doaj   +1 more source