Results 81 to 90 of about 1,697 (183)

A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer

Basic & Clinical Cancer Research
Enterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways,
Abolfazl Jafari-Sales, Maryam Farahnaki-Sadabadi, Elham Nozohour-Leilabadi, Negin Yagoubi Azar, Maryam Safari, Mehrdad Pashazadeh   +5 more
doaj   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, Volume 2, Issue 1, March 2026.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

The myeloid immune signature of Enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis [PDF]

, 2018
Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of IL-17-dependent colon tumorigenesis in Min mice.
Thiele Orberg, Erik Thiele
core  

Supplementary Figure 2 from Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis

, 2015
IL-17+ Foxp3+ Tregs infiltrate ETBF-infected colons. Min mice were inoculated with ETBF on day 0. At 10 weeks, colonic LPLs were harvested from colon tumors (left) and adjacent non-tumor colon tissue (right).
Xinqun Wu (11611624), Jaime L. Wolfe (15101076), David L. Huso (14883036), Drew M. Pardoll (8689350), Franck Housseau (6323741), Abby L. Geis (5830169), Hongni Fan (6323693), Cynthia L. Sears (7545743), Shaoguang Wu (7545731)   +8 more
core   +1 more source

A Robust Métier-Based Approach to Classifying Fishing Practices Within Commercial Fisheries

Frontiers in Marine Science, 2020
Developing a typology of heterogeneous fishing practices through the use of métier analysis is a useful step in understanding the dynamics of fishing fleets and enabling effective implementation of management outcomes.
Mahdi Parsa, Timothy J. Emery, Ashley J. Williams, Simon Nicol, Simon Nicol   +4 more
doaj   +1 more source

Evaluation of the prevalence of enterotoxigenic Bacteroides fragilis and the distribution bft gene subtypes in patients with diarrhea

, 2010
The aim of this study was to determine the prevalence of enterotoxigenic Bacteroides fragilis (ETBF) in the patients with diarrhea in our region and to assess the association between diarrhea and bft gene subtypes.
Füsun Cömert, Mehtap Akpınar, Vildan Sümbüloğlu, Canan Külah, Elif Aktaş   +4 more
core   +1 more source

Supplementary Table S3 from Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy

, 2021
Differential expression (DESeq2) tables of RNAseq analysis for sham and ETBF-colonized normal epithelium and tumors from Min and BRAFV600ELgr5CreMin (BLM) colons.
Alyssa Wenzel (15117298), James R. White (9416009), Jessica L. Hicks (11054040), Douglas B. Rusch (7478597), Christina E. DeStefano Shields (15117295), Ram Podicheti (2142478), Shruthi Sriramkumar (14950968), Cynthia L. Sears (15036183), Sepideh Besharati (15035028), Franck Housseau (6323741), Liam Chung (8689347), Robert A. Anders (10076582), Heather M. O'Hagan (14950980), Angelo M. De Marzo (14953540), June L. Chan (15117301), Ada J. Tam (15023043), Ashley R. Maiuri (6880529), John Michel (15117307), Stephen B. Baylin (9706753), Christine M. Dejea (15117304), Hongni Fan (6323693), Hao Wang (39217)   +21 more
core   +1 more source

A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

, 2006
The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B.
ÜLGER, NURVER, KARAHASAN, AYŞEGÜL, GÜLLÜOĞLU, MAHMUT BAHADIR   +2 more
core   +2 more sources

Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy

, 2021
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota.
De Marzo, Angelo M., Wenzel, Alyssa, Michel, John, Rusch, Douglas, Anders, Robert, Anders, Robert A., O’Hagan, Heather M., Chan, June, Sears, Cynthia, L, Maiuri, Ashley R., Dejea, Christine, Chung, Liam, Sears, Cynthia L., Tam, Ada, Hicks, Jessica, de Marzo, Angelo, Baylin, Stephen, Destefano Shields, Christina, Besharati, Sepideh, DeStefano Shields, Christina E., Rusch, Douglas B., Housseau, Franck, Hicks, Jessica L., Baylin, Stephen B., White, James, Fan, Hongni, Tam, Ada J., Podicheti, Ram, White, James R., Dejea, Christine M., Sriramkumar, Shruthi, O'Hagan, Heather, Maiuri, Ashley, Chan, June L., Wang, Hao, Stephen B. Baylin, Angelo M. De Marzo, Cynthia L. Sears, Ram Podicheti, Christina E. DeStefano Shields, Shruthi Sriramkumar, Alyssa Wenzel, Sepideh Besharati, John Michel, Ada J. Tam, Heather M. O'Hagan, James R. White, Franck Housseau, Liam Chung, Robert A. Anders, Jessica L. Hicks, Ashley R. Maiuri, Hao Wang, Christine M. Dejea, Hongni Fan, June L. Chan, Douglas B. Rusch   +56 more
core   +1 more source

Receptor-guided proteolysis at the host-gut microbiota interface: insights from the Bacteroides fragilis toxin-claudin-4 axis

Targetome
Enterotoxigenic Bacteroides fragilis (ETBF) is a colorectal cancer-associated bacterium whose pathogenicity depends largely on B. fragilis toxin (BFT), a secreted metalloprotease that cleaves E-cadherin and disrupts epithelial barrier integrity.
Danni Tong, Weiwei Zheng, Frank J. Gonzalez, Yuhong Luo   +3 more
doaj   +1 more source